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AM

ammonium lactate

✓ Approved

Bristol-Myers Squibb · Small Molecule · Small Molecule

What is ammonium lactate?

ammonium lactate is a small molecule developed by Bristol-Myers Squibb. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyBristol-Myers Squibb
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Bristol-Myers Squibb

Therapeutic Indications

ammonium lactate is developed for 3 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersIchthyosis✓ Approved
Skin and subcutaneous tissue disordersPruritus✓ Approved
General disorders and administration site conditionsXerosis✓ Approved

Related Research Articles

PubMedBioanalysis2026-10-16

Optimization of hemolysis index thresholds for biochemical and immunoassays.

Dupuy Anne Marie AM, Tabone Delphine D, Coulon Caroline C, Morena Marion M et al.

Our study aimed at establishing analyte-specific hemolysis-index thresholds on 18 chemistry assays to avoid re-sampling on Atellica© Solution (Siemens Healthcare Diagnostics, Los Angeles, CA, USA). We focused on the analytes which showed the highest degree of hemolysis interference at one or two baseline concentrations for the following 18 analytes: ALT (alanine aminotransferase), ammonium, AST (aspartate aminotransferase), CK (creatine kinase), creatinine, folates, FSH (follicle stimulating hormone), GGT (γ-glutamyltransferase), Hp (haptoglobin), iron, insulin, LD (lactate dehydrogenase), lipase, potassium, urea, uric acid, vitamins B12, and D. Interference was quantified as a percentage difference from the Hb-free baseline sample. Each calculated bias was compared to the four cutoffs: 10%Δ, analytical change limit, total change limit, or reference change limit. Analytes that did not exceed the predefined allowable-bias criterion for hemolysis included creatinine, FSH, GGT, iron, urea, uric acid, and vitamin B12. Among the affected analytes, the largest positive and negative biases were observed for AST, folates, LD, and potassium. The principal quantitative optimized thresholds for the hemolysis-sensitive analytes were AST, folates, iron, potassium, and LD tests. Our study allowed us to supplement the data provided by the manufacturer and to optimize the thresholds for interference with hemolysis management of hemolyzed samples.

PMID 42885504
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PubMedInternational journal of molecular sciences2026-10-16

Folate Deficiency Drives Metabolic Dysfunction, Oxidative Stress, and Inflammation in HK-2 Renal Tubular Cells.

Chiu Te-I TI, Liu Hsiang-Yu HY, Lin Bi-Fong BF

The growing aging population has been accompanied by an increasing prevalence of chronic kidney disease (CKD), highlighting the need to better understand modifiable dietary and metabolic factors that contribute to renal injury. Folate deficiency and excessive fructose intake have been implicated in renal inflammation; however, the underlying cellular mechanisms remain incompletely understood. In this study, we investigated the effects of folate deficiency or fructose exposure on inflammatory responses, lactate metabolism, oxidative stress, and mitochondrial function in human renal tubular epithelial HK-2 cells. Folate deficiency markedly increased the secretion of the pro-inflammatory cytokines interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), accompanied by enhanced NF-κB activation, both in the presence and absence of lipopolysaccharide (LPS) stimulation. Notably, folate-deficient cells exhibited increased lactate dehydrogenase (LDH) activity, intracellular lactate accumulation, and lactate secretion. Exogenous lactate supplementation or modulation of lactate production using the LDH inhibitor oxamate further demonstrated that elevated lactate promoted IL-6 and transforming growth factor-β1 (TGF-β1) production, NF-κB activation, and reactive oxygen species (ROS) generation. Consistent with these findings, folate deficiency significantly reduced the oxygen consumption ratio (OCR), indicating impaired mitochondrial function and a metabolic shift away from oxidative phosphorylation toward increased lactate production. High fructose exposure also enhanced IL-6 and MCP-1 secretion, particularly following LPS stimulation, while both LPS exposure and folate deficiency further increased lactate production. Collectively, these findings identify lactate accumulation as a potential metabolic link between folate deficiency, inflammation, oxidative stress and fibrotic signaling in renal tubular HK-2 cells. This metabolic-inflammatory pathway may contribute to the initiation and progression of CKD and highlights folate status and lactate metabolism as potential targets for preventing diet-associated renal injury.

PMID 42884089
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PubMedPolymers2026-10-16

Preparation and Characterization of Immediate-Release Tablets Containing Calcium Lactate Recovered from Chemically Recycled Poly(lactic acid) 3D Printing Filaments.

Attallah Olivia A OA, Brandao Dario D, Tran Jacqueline J, Rivera Irvin I et al.

Polylactic acid (PLA) is one type of biodegradable plastic that can replace single-use plastic. Nevertheless, it still poses the problem of accumulation in the environment due to the slow biodegradation rate. Developing simple yet effective methods for PLA recycling and upcycling can pave the way for a circular economy and help partially solve the plastic pollution problem. In the present work, PLA filaments of different colors were chemically recycled in alkaline solutions of C1-C3 primary alcohols under mild experimental conditions (75 °C for 30 min, 1 atm). The effect of various process parameters such as depolymerization solvent media and PLA pigmentation on the percentage of PLA depolymerization and Ca lactate monomer yield was studied. PLA filament size was also investigated as a factor affecting the kinetics of PLA depolymerization. As a monomer, Ca lactate was evaluated by different characterization techniques including Fourier transform infrared spectroscopy, Nuclear Magnetic Resonance, and Atomic Absorption Spectroscopy. In addition, the powder quality was tested against US Pharmacopeia standards for acidity, heavy metal presence, hydration state, and calcium content. The recycled Ca lactate was formulated with other ingredients into Ca lactate tablets via direct compression to serve as a calcium source for preventing and treating calcium deficiencies. The tablet characteristics were compared against commercially available Ca supplements with respect to shape consistency, uniformity of calcium loading, immediate release, and cytotoxicity. The obtained findings suggest that there exists a viable, environmentally friendly avenue for utilizing PLA recycling products in the development of compounds with potential applications in the pharmaceutical domain.

PMID 42885052
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PubMedACS sensors2026-10-16

Dual-Function Microneedle Patch for Retinyl Acetate Delivery and Lactate Sensing in Skincare Management.

Wu Tingting T, Liu Guozhen G

Closed-loop skin health management that integrates real-time diagnostic feedback with on-demand therapeutic delivery remains a critical unmet challenge in precision dermatology. Here, a smart core-shell microneedle (MN) patch is developed for bidirectional skin intervention: simultaneous delivery of retinyl acetate (RA) therapy and in situ monitoring of interstitial fluid (ISF) lactate as a metabolic biomarker. RA is first encapsulated in hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complexes via a rapid ultrasonic method to enhance solubility and stability. The MN patch features a mechanically robust polyvinyl alcohol/sodium hyaluronate (PVA/SH) shell for effective stratum corneum penetration and a hyaluronic acid-based core loaded with RA@HPβCD, type I collagen, and chitosan for synergistic anti-aging and anti-acne effects. The MN patch delivers RA to remodel the dermal matrix while continuously extracting ISF, enabling on-site quantitative analysis of lactate as a metabolic feedback indicator of skin status-elevated lactate signals skin hypoxia or inflammation, prompting timely RA action. This integrated platform thereby establishes a closed-loop system coupling therapeutic intervention with diagnostic assessment. This smart MN patch offers a promising strategy for precision skin care and holds potential for managing diverse dermatological conditions requiring dynamically adjustable therapy.

PMID 42881508
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PubMedEuropean journal of pediatrics2026-10-16

Lactate-albumin ratio as an early predictor of mortality in critically ill children: A prospective cohort study.

C Hari Prasath HP, Kumar P Anil PA

Early risk stratification in critically ill children relies on severity scores such as PRISM-III and PELOD-2, requiring multiple variables. The lactate-albumin ratio (LAR), a two-parameter marker, shows prognostic value in adult and paediatric critical illness. This study evaluated serial LAR for predicting PICU mortality and compared its performance at admission against PRISM-III and PELOD-2. This prospective cohort study enrolled 335 of 563 screened children aged 1 month to less than 13 years admitted to a tertiary-care PICU in South India over 12 months. Serum lactate and albumin were measured at 0, 12, 24, and 48 h. Discriminatory performance was assessed using ROC curve analysis with DeLong's test. Firth-penalized multivariable logistic regression identified independent predictors. Of 335 children, 42 (12.5%) were non-survivors. LAR at admission discriminated mortality with an area under the curve (AUC) of 0.859 (95% CI 0.806-0.907), exceeding PRISM-III (AUC 0.751) and PELOD-2 (AUC 0.759) at the same timepoint (p < 0.05 for both). LAR remained independently associated with mortality after adjustment for PRISM-III, sepsis, and vasoactive support (adjusted odds ratio 3.77, 95% CI 2.22-6.40, p < 0.001), and outperformed lactate and albumin. LAR remained persistently elevated in non-survivors through 48 h.Conclusions: LAR at admission discriminated PICU mortality better than PRISM-III and PELOD-2 and remained an independent predictor after adjustment. Serial LAR changes may be a useful adjunct in predicting prognosis, though their clinical utility requires further prospective study. Derived from two routine investigations, LAR may serve as a practical addition to severity scoring, pending external validation. What is Known • Mortality risk in critically ill children is estimated with multivariable severity scores such as PRISM-III and PELOD-2. • Lactate and albumin refl ect tissue perfusion and systemic infl ammation, and their ratio has been associated with mortality in critical illness. What is New • We hypothesised that the lactate-albumin ratio, from two routine blood tests, may predict PICU mortality at least as well as multivariable severity scores. • We also hypothesised that serial measurement over the fi rst 48 hours may add prognostic information beyond the admission value.

PMID 42881277
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PubMedJournal of clinical medicine2026-10-16

Preoperative Inflammatory Risk Markers and Postoperative Creatinine and Lactate as Mortality Markers After Surgery for Stanford Type A Acute Aortic Dissection.

Önder Rauf R, Özçobanoğlu Salih S

Objective: The primary objective was to evaluate the association between preoperative platelet-to-lymphocyte ratio (PLR), measured at admission, and 30-day mortality after emergency surgical repair for Stanford type A acute aortic dissection (TAAD). Secondary analyses evaluated other preoperative inflammatory and biochemical markers, postoperative biomarker measurements as indicators of evolving postoperative physiology, and their associations with 2-year mortality. Methods: This retrospective study included 506 patients who underwent emergency surgery for TAAD. Preoperative and postoperative laboratory parameters-including creatinine, sodium, potassium, lactate, NLR, PLR, SII, and MLR-were collected along with perioperative clinical variables. Group comparisons were performed according to 30-day and 2-year mortality outcomes. Spearman correlation analysis was used to assess associations between biomarkers and clinical parameters. Receiver operating characteristic (ROC) analyses were conducted to determine the discriminative performance of inflammatory indices and biochemical markers. Statistical significance was defined as p < 0.05. Results: Non-survivors had significantly higher preoperative and postoperative creatinine levels (p = 0.008 and p = 0.003), longer aortic cross-clamp and circulatory arrest times (both p < 0.001), and elevated postoperative lactate levels (p = 0.029). All inflammatory indices-including NLR, PLR, and SII-were markedly higher in patients who died within 30 days (all p < 0.001). MLR was also significantly elevated in non-survivors, although the magnitude of increase was more modest compared with the other inflammatory indices (preoperative p = 0.011; postoperative p = 0.007-0.010). In the primary analysis, preoperative PLR showed good discrimination for 30-day mortality (AUC 0.819, 95% CI 0.750-0.889) and remained independently associated with 30-day mortality after adjustment for age, preoperative creatinine, aortic cross-clamp time, and total circulatory arrest time (adjusted OR 1.004, 95% CI 1.002-1.007; p < 0.001). Postoperative inflammatory indices, creatinine, and lactate were also associated with mortality and were interpreted as markers of evolving postoperative physiological deterioration, whereas sodium showed no meaningful prognostic contribution. For 2-year mortality, elevated preoperative and postoperative creatinine and lactate levels, together with persistently higher inflammatory indices at all measured time points, were significantly associated with long-term death (all p < 0.001). No inflammatory index showed a meaningful correlation with postoperative complications. Conclusions: Preoperative PLR was associated with 30-day mortality after TAAD surgery. Postoperative inflammatory indices; creatinine; and lactate were also associated with mortality but may primarily have reflected evolving postoperative physiological deterioration. Prospective multicenter validation is required before these biomarkers are incorporated into clinical risk models or used to guide management decisions.

PMID 42882075
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