Drug Database
N-

N-1037

✓ Approved

Bausch Health Companies Inc. · Small Molecule · Small Molecule

What is N-1037?

N-1037 is a small molecule developed by Bausch Health Companies Inc.. It is approved for therapeutic indications via others or inhaled or topical.

Drug Profile

CompanyBausch Health Companies Inc.
Drug ClassSmall Molecule
RouteOthers, Inhaled, Topical
StatusApproved
Sources: ClinicalTrials.gov, Bausch Health Companies Inc.

Therapeutic Indications

N-1037 is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Eye disordersConjunctivitis allergic✓ Approved
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

Related Research Articles

PubMedMarine life science & technology2026-08-30

Marine polysaccharide-based multifunctional composite sponge for rapid hemostasis and enhanced infected wound healing.

Fan Yinuo Y, Liu Kaihua K, Wang Chunxiao C, Zhang Xinyu X et al.

Uncontrolled bleeding and bacterial infections are major impediments to wound healing. Developing a wound dressing for the skin that possesses both antimicrobial properties and effective hemostatic capabilities is crucial. In this study, a marine polysaccharide-based multifunctional composite sponge was fabricated via chemical cross-linking approach and freeze-drying process. We structurally blended chitosan (CS) with hematite nanotubes (HNT) possessing hemostatic activity. HNT not only effectively promotes blood coagulation by activating coagulation factors but also significantly enhances the structural stability and mechanical properties of the chitosan matrix as a nano-reinforcing agent. Inspired by marine mussel adhesion, polydopamine (PDA) was employed to convert silver ions (Ag+) into silver nanoparticles (PDA@Ag). They were uniformly embedded and stabilized in CS sponges to enhance sustained antimicrobial effects and mitigate cytotoxicity. Compared with gauze, the CS/HNT/PDA@Ag sponge demonstrated excellent hemostatic performance. In rat tail injury experiments, the time to hemostasis was reduced from 89.3 s to 18 s, and blood loss was reduced from 898 to 260 mg. In rat liver injury experiments, the time to hemostasis was reduced from 121 s to 28.7 s, and blood loss was reduced from 1037 to 159 mg. The addition of Ag NPs and the subsequent release of ions significantly reduced bacterial survival rates (> 95%). In a rat full-thickness skin defect infection model, the healing rate of CS/HNT/PDA@Ag sponge reached 99.8% at 14 days of implantation, which effectively promoted collagen deposition, neovascularization and wound healing. By combining the natural biocompatibility of marine-derived CS with the synergistic effects of HNT and mussel-inspired PDA@Ag, the composite sponges offer a highly effective solution for hemostasis and infected wound healing. The online version contains supplementary material available at https://doi.org/10.1007/s42995-026-00413-1.

PMID 42668670
Read full article →
PubMedANZ journal of surgery2026-08-30

Validation of a Three-Dimensional Handheld Scanner in Measuring Breast Anthropometrics.

Holek Andrea A, Meng Mathilde R Desselle MRD, Chapman Gwenda G, Byram Isabel I et al.

Outcomes in aesthetic breast surgery are dependent on accurate pre-operative breast measurements. The accuracy of large scale 3-dimentional scanners has been reported, the use of handheld scanners has not been described. The authors aimed to determine the trueness of anthropometric measurements of breasts obtained from a handheld 3D scan compared to direct measurements. Three raters measured the breasts of 19 women using three anthropometric measurements (direct) measurements: sternal notch to nipple (Sn-N), nipple to inframammary fold (N-IMF), base width (BW). The measurements were taken directly by two raters using a measuring tape, and digitally by one rater using the software on 3D scans acquired with the Artec Leo handheld 3D scanner. Statistical analysis was completed with Bland-Altman plots as well as scatter plots to identify bias between the two methods. The study found that the 3D scanner showed varying levels of bias when compared to direct breast measurements. Sn-N measurement showed smaller differences, while the N-IMF and BW measurements exhibited larger discrepancies. The 3D scanning process was significantly faster, taking only 30 s per scan, compared to roughly 5 min for direct measurements, with an additional 10 min for image processing and digital measurements. Three-dimensional scanning is most accurate for Sn-N and is more variable when measuring BW and N-IMF due to obscured landmarks on frontal imaging. The BW and N-IMF measurements also showed the most inter-rater variability. Consistent with previous research 3D scanning has limited trueness when measuring N-IMF as it is a dynamic measurement.

PMID 42669600
Read full article →
PubMedCureus2026-08-30

Clinical Efficacy and Patient Adherence Hurdles of Remote Patient Monitoring (RPM) Frameworks in Managing Hypertension and Type 2 Diabetes: A Scoping Review.

Athukorala Susith C SC

Remote patient monitoring (RPM) frameworks represent a critical paradigm shift in chronic disease management, enabling continuous physiological tracking outside traditional clinical environments; however, large-scale clinical deployment is frequently bottlenecked by operational attrition, patient compliance barriers, and therapeutic provider inertia. This scoping review maps the global evidence regarding the technical configurations, data integration architectures, and human factor friction points that dictate the implementation efficacy of RPM platforms for hypertension and type 2 diabetes. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) consensus standards, a systematic search was executed across PubMed, Embase, and Scopus, utilizing a hybrid data extraction approach combining manual triage with a local, regular expression-driven text-mining pipeline to chart a final corpus of 400 full-text peer-reviewed source publications, yielding 701 distinct technical and operational evaluation entries. The comprehensive data charting pipeline mapped exactly 701 unique architectural and behavioral evaluation layers across the included literature. Quantitative synthesis indicated that automated upper-arm oscillometric blood pressure cuffs constituted the primary remote monitoring hardware (32.8%; n=230), while continuous glucose monitors/glucometers and wearable sensors demonstrated symmetrical distributions (11.1%; n=78 each). Ingestion architectures heavily favored automated, passive cloud-native uplinks (43.2%; n=303) over short-range active Bluetooth middleware pairing (19.4%; n=136). Implementation barrier cross-tabulation revealed that clinical workflow friction and daily routine disruption constituted the single most prevalent deployment bottleneck (27.1%; n=190). Patient-centric human factors included digital health literacy gaps (15%; n=105) and technology anxiety or alert fatigue (9.3%; n=65), while systemic provider therapeutic inertia was documented in 8.4% (n=59) of settings. Bivariate co-occurrence analysis established that operational workflow friction frequently compounded alongside digital literacy deficiencies (n=10) and clinical inertia (n=7). Ultimately, RPM deployment longevity is directly governed by technical architecture selections and the optimization of downstream clinician workflows. To minimize patient attrition and avoid technical debt, future health informatics implementations must move past isolated device deployments, prioritizing semantic interoperability via Health Level Seven (HL7) Fast Healthcare Interoperability Resources (FHIR) standards.

PMID 42668925
Read full article →
PubMedJournal of nephrology2026-08-30

Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease.

Yıldırım Uz Büşra B, Güneş Gencer Gökçe Yağmur GY, Bora Feyza F

Evidence on the effects of 12-week telehealth-supported home-based exercise in advanced non-dialysis chronic kidney disease (CKD) remains limited. This study evaluated its effects on functional capacity, sarcopenia risk, and patient-reported outcomes in patients with stage 4-5 CKD. In this prospective, parallel-group randomized controlled trial (October 2024-July 2025), 54 non-dialysis patients aged ≥45 years with stage 4-5 CKD were randomized 1:1 to a 12-week telehealth-supported home-based exercise program plus usual nephrology care or usual care alone. Complete-case analyses included 51 participants (exercise group: n = 25 [stage 4, n = 21; stage 5, n = 4]; control group: n = 26 [stage 4, n = 20; stage 5, n = 6]). The primary outcome was change in 6-minute walk test distance. Secondary outcomes included physical performance, sarcopenia risk, fatigue, mood symptoms, sleep quality, and health-related quality of life. Fifty-one participants completed the study (exercise group, n = 25; control group, n = 26). Compared with controls, the exercise group showed a greater improvement in 6-minute walk test distance (+29.41 ± 35.63 m vs -19.27 ± 33.62 m; P < .001), which remained significant after covariate adjustment. Significant improvements were also observed in sarcopenia risk, fatigue, mood symptoms, sleep quality, physical performance, and quality of life. Among intervention participants, 40% used the web-based platform and 60% received video-based support. A 12-week telehealth-supported home-based exercise program significantly improved functional capacity and multiple patient-reported outcomes in patients with non-dialysis stage 4-5 CKD.

PMID 42669568
Read full article →
PubMedReproductive biomedicine online2026-08-30

Impact of combining fast vitrification and fast warming protocols on live birth outcomes.

Arkfeld Christopher K CK, Vagios Stylianos S, Minis Evelyn E EE, Fitz Victoria W VW et al.

Does the combination of fast vitrification and fast warming protocols, compared with standard vitrification and standard warming protocols, result in differences in pregnancy outcomes following frozen embryo transfer (FET)? This was a retrospective comparative cohort study of unique patients undergoing either natural, medicated or programmed FET cycles of single blastocysts. The first FET following fresh cycles was included for each patient. Three groups were analysed: standard vitrification with standard warming protocol (n = 1025); standard vitrification with fast warming protocol (n = 926); and fast vitrification with fast warming protocol (n = 471). The primary outcome was live birth rate. Secondary outcomes included positive pregnancy test rate, biochemical pregnancy rate, clinical pregnancy rate and miscarriage rate. Logistic regression models were performed, controlling for day of cryopreservation (day 5 or day 6), FET preparation, body mass index and oocyte age. A subanalysis was performed on embryos that underwent preimplantation genetic testing for aneuploidy (PGT-A). Unadjusted analysis showed no difference in live birth rate (42.5% versus 41.8% versus 46.9%; P = 0.167), pregnancy rate (58.8% versus 56.3% versus 62.4%; P = 0.085), biochemical pregnancy rate (8.9% versus 8.1% versus 8.5%; P = 0.827), clinical pregnancy rate (49.6% versus 48.1% versus 53.3%; P = 0.179), and spontaneous abortion rate (6.9% versus 6.0% versus 6.2%; P = 0.704) across the standard vitrification-standard warming, standard vitrification-fast warming, and fast vitrification-fast warming groups, respectively. These findings remained unchanged in the adjusted analysis. A subanalysis of PGT-A embryos showed no difference in live birth rate (45.1% versus 46.2% versus 49.6%; P = 0.472) between the standard vitrification-standard warming (n = 548), standard vitrification-fast warming (n = 424), and fast vitrification-fast warming (n = 266) groups, respectively. The fast vitrification-fast warming protocol for vitrified and warmed blastocyst-stage embryos is as effective as the standard vitrification-standard warming protocol, demonstrating no negative impact on live birth or secondary outcomes.

PMID 42669220
Read full article →
PubMedPediatric research2026-08-30

Serum and urinary D-lactate in pediatric intestinal failure: clinical associations and reference values.

Halašová Rita R, Ibrahim Rana R, Balogová Stanislava S, Štichhauer Radek R et al.

D-lactate, produced by intestinal microbiota or derived from the methylglyoxal pathway and diet, is converted by D-lactate dehydrogenase (LDHD) to pyruvate, with several known pathogenic variants of the gene. This study compared serum and urinary D-lactate concentrations across five patient groups and established reference values in healthy children. In this cross-sectional study, 341 serum and urine samples from 129 pediatric patients were analyzed. The cohort comprised patients receiving home parenteral nutrition (PN, n = 19), after bowel adaptation (ADAPT, n = 28), with gastrostomy feeding (PEG, n = 13), other gastrointestinal disorders (GI, n = 14), and healthy controls (HC, n = 55). D-lactate was measured via enzymatic spectrophotometric assay. A genetic sub-analysis assessed pathogenic LDHD variants. Median serum and urinary D-lactate concentrations in healthy controls were 28.5 μmol/L (IQR 25-34.25) and 400 μmol/L (IQR 193-722), respectively. Both serum (p < 0.001) and urine (p = 0.011) D-lactate concentrations were higher in the ADAPT group compared to healthy controls. No pathogenic LDHD variants were identified. Children after bowel adaptation have higher serum and urine D-lactate concentrations compared to healthy controls. Reference values for serum and urinary D-lactate were defined. This is the first study to provide reference values for serum and urinary D-lactate concentrations in healthy children (serum: 28.5 µmol/L (IQR: 25-34.25 µmol/L); urine: 400 µmol/L (IQR: 193-722 µmol/L)). Children after bowel adaptation exhibited higher D-lactate concentrations in both serum and urine compared to healthy controls. Higher serum and urinary D-lactate levels were associated with the presence of an intestinal anastomosis.

PMID 42668282
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about N-1037