Drug Database
N-

N-1037

✓ Approved

Bausch Health Companies Inc. · Small Molecule · Small Molecule

What is N-1037?

N-1037 is a small molecule developed by Bausch Health Companies Inc.. It is approved for therapeutic indications via others or inhaled or topical.

Drug Profile

CompanyBausch Health Companies Inc.
Drug ClassSmall Molecule
RouteOthers, Inhaled, Topical
StatusApproved
Sources: ClinicalTrials.gov, Bausch Health Companies Inc.

Therapeutic Indications

N-1037 is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Eye disordersConjunctivitis allergic✓ Approved
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

Related Research Articles

PubMedInfluenza and other respiratory viruses2026-10-16

Genome-Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID-19.

Xue Xiao X, Feng Yaning Y, Lin Yu-Ping YP, Chan Pui-Ching PC et al.

Influenza remains a significant global health burden, potentially leading to hospitalization and mortality. Although previous studies have explored genetic susceptibility to influenza infection, the genetic basis of influenza hospitalization and its relationship with respiratory diseases like COVID-19 remain poorly understood. We performed a binary GWAS of hospitalized influenza using UK Biobank data (UKBB; 1037 cases/404,108 controls) and then meta-analyzed results with the FinnGen GWAS, yielding 11,171 cases and 782,400 controls. A time-to-event GWAS in UKBB was also performed to identify genetic factors underlying the timing (age) of first influenza hospitalization. p-values from both analyses were integrated by the harmonic mean p-value (HMP) method to enhance association detection. Further differentiation and colocalization analyses with COVID-19 investigated their distinct and shared genetic features. An integrative framework combining functional annotations, multi-omics analyses, and phenome-wide scans prioritized key risk and differential genes. The binary GWAS meta-analysis identified three loci (ST6GAL1, AASDHPPT, SPATS2L) associated with hospitalization risk. The time-to-event GWAS recognized UGT2B4 as linked to hospitalization timing. HMP analysis, which combines evidence across the binary and time-to-event analyses, identified ST6GAL1 (p = 3 × 10-9) and UGT2B4 (p = 3.63 × 10-8) as genome-wide significant; however, each signal was driven predominantly by one component test, ST6GAL1 by the binary meta-analysis (meta p = 1.5 × 10-9), and UGT2B4 by the time-to-event analysis (SPACox p = 1.82 × 10-8), rather than showing independent support from both analyses. Differentiation analysis identified 29 loci and two tissues distinguishing influenza from COVID-19, whereas analysis of shared association signals (cofdr) highlighted candidate shared genetic factors, including ST6GAL1 and ICAM5 (gene-level PPA ≥ 0.9). This study uncovers the genetic architectures of hospitalized influenza. It also highlights genetic differences and similarities with COVID-19, providing hypothesis-generating insights that may inform future functional and therapeutic research.

PMID 42885252
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PubMedTree physiology2026-10-16

Nitrogen physiology and metabolism of two contrasting Catalpa bungei genotypes in response to limited nitrogen availability.

Zhou Mengyan M, Zhou Jing J, Wu Jiangting J, Jia Chenlin C et al.

To investigate N physiology and metabolism of different Catalpa bungei (C. bungei) genotypes in response to low N availability, saplings of a genotype (Cbu22-03) with high N uptake efficiency and a genotype (CbuGu) with low N uptake efficiency were exposed to 10, 100, or 1000 μM NH4NO3. The greater root biomass and fine-root surface area in Cbu22-03, combined with its higher net influxes of NO3- and NH4+ and upregulated transcript levels of CbuNRT1.1 and CbuAMT1.2, corresponded to the increased NO3- and NH4+ concentrations and total N amounts in roots compared with CbuGu. Accordingly, δ15N in both roots and leaves of Cbu22-03 was lower than that of CbuGu. Low N supply led to decreased net influxes of NO3- and NH4+, and reduced NO3-/NH4+ concentrations of roots and leaves, NR activities, and total N amounts, while inducing the up-regulation of CbuNRT1.1, CbuAMT1.2, and CbuAHA2 transcript levels, which likely enhanced nitrogen use efficiency (NUE) in both genotypes. These data suggest that Cbu22-03 shows greater capacities of N uptake and assimilation than CbuGu under the three N conditions, and both genotypes of C. bungei decreased the processes of N metabolism in response to low N availability.

PMID 42886010
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PubMedSeminars in ophthalmology2026-10-16

Clinical Spectrum and Insights from One Year of Ocular Genetics at a Single Tertiary Eye Care Centre.

Chattannavar Goura G, Mupparapu Vyshnavika V, Maragani Rachana R, Sadhu Pravalika P et al.

Genetic testing benefits individuals and families with inherited eye diseases by facilitating accurate diagnosis, informing prognosis, enabling assessment for at-risk family members, and supporting targeted therapies. This study aimed to characterize the spectrum of inherited eye disorders and evaluate the diagnostic yield of genetic testing at a single tertiary eye care centre over a one-year period. A retrospective review of patients attending the ocular genetics service at a tertiary eye care centre in India from January 1 to December 31, 2024, was conducted. Of 1325 patients evaluated, 862 (65%) underwent genetic testing. Inherited retinal disorders were the most common (n = 440, 51%), followed by cornea and anterior segment disorders (n = 107, 12.4%). Other conditions included hereditary optic nerve disorders (n = 75, 8.7%), glaucoma (n = 70, 8.1%), lenticular disorders (n = 54, 6.3%), phacomatoses (n = 25, 2.9%), ocular tumours (n = 20, 2.3%), strabismus and albinism (n = 19 and 18; ~2% each), MAC spectrum disorders (n = 10, 1.4%), and systemic syndromes (n = 22, 2.5%). Diagnostic yield was achieved in 605 (70%), while 257 (30%) remained inconclusive. Of the 463 untested families, the motivations were unascertained reasons (n = 156, 33%), financial constraints (n = 138, 30%), intent to test later (n = 90, 19%), and belief that no treatment was available (n = 79, 17%). Inherited retinal and anterior segment disorders constitute the most frequent genetic eye diseases. Genetic testing has enabled genotype-phenotype correlation in over two-thirds of cases. Financial constraints and limited availability of disease-modifying treatments remain key barriers for uptake of genetic testing.

PMID 42885952
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PubMedPlants (Basel, Switzerland)2026-10-16

Film Mulching with Straw Return and Controlled-Release and Conventional Urea Blend Alters Aggregate-Associated Nitrogen Distribution While Sustaining Grain Yield in Dryland Maize.

Zhang Fangfang F, Lv Yixuan Y, Lu Yanting Y, Song Ziyi Z et al.

Plastic film mulching (FM) improves crop productivity in dryland agriculture but risks soil quality degradation under continuous chemical fertilization. Under FM with optimized nitrogen (N) input from a controlled-release and conventional urea blend (CCU), straw return (SR) management may either contribute to grain yield or alter aggregate-associated N pools. A two-year film-mulched experiment was conducted with three treatments: no fertilization (CK), CCU alone (CU), and CCU plus SR (CS). Compared with CU, CS did not further increase grain yield despite greater total N uptake during critical growth stages. However, CS increased the proportion of large macroaggregate (LM) by an average of 10.0 percentage points and the mean weight diameter by 35.7%, and also increased N concentration in most aggregate fractions. A significant increase in N stock was detected in the LM fraction in both years. In contrast, N stock in the microaggregate (MI) was significantly lower under CS in 2020, whereas N stocks in small macroaggregate (SM), silt and clay (SC), and bulk soil were not significantly affected in either year. SM N stock was positively correlated with grain yield in the pooled dataset, but this association was attenuated after controlling for year and should therefore be considered exploratory. Overall, CS maintained grain yield comparable to CU while altering aggregate-associated N distribution, suggesting a potential decoupling between short-term yield and aggregate-associated N pools; however, the origin of the additional aggregate-associated N could not be resolved without isotopic tracing.

PMID 42884908
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-10-16

Tuning N-Species Adsorption/Desorption Equilibrium by Ni1Aun-SrTiO3 for Artificial Urea Photosynthesis.

Li Dong D, Zhai Shaochuan S, Wang Jinhu J, Gao Junyu J et al.

Inefficient generation of N-related intermediates, stemming from inert adsorption/photoactivation of N2, has hindered efficient artificial photosynthesis of urea from N2, CO2, and H2O. To overcome this bottleneck, we herein propose a strategy for modulating the adsorption/desorption equilibrium of N-related species using precisely designed bimetallic Ni1Aun active sites supported on a strontium titanate (NiAu-STO) semiconductor photocatalyst. This strategy significantly enhances N2 adsorption/activation and effective generation of N-related intermediates to facilitate C-N coupling for the photocatalytic urea synthesis, affording a considerable urea production rate of 1333.63 µg gcat. -1, with successful crystallization of a collectible solid-phase urea product. Furthermore, we developed a novel reaction-temperature programmed desorption-mass spectrometry tandem monitoring system to elucidate the adsorption behavior of N2, which can clarify the adsorption behavior of N2 and confirm the formation of critical N-related intermediates (e.g., *NH2) on the NiAu-STO photocatalyst. In addition, in situ Raman spectroscopy results further validated the formation of a distinctive C-N coupling intermediate (*NH2COO-) on the photocatalyst surface, providing mechanistic insights into urea photosynthesis from N2, CO2, and H2O.

PMID 42885862
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PubMedMolecules (Basel, Switzerland)2026-10-16

Synthesis and Photophysical Study of [(C^N^C)Au(L)]n+ Pincer Complexes, L = Alkynyl (n = 0), Isocyanide (n = +1): Comparative Analysis of Their Aggregation Behavior.

Durova Elizaveta V EV, Stroeva Arina S AS, Kisel Kristina S KS, Kinzhalov Mikhail A MA et al.

Two series of Au(III) pincer complexes [(C^N^C)AuL]n+ (C^N^C = 2,6-diphenylpyridine, L = alkynyl, n = 0; L = isocyanide, n = 1) have been synthesized and characterized in solution by NMR spectroscopy and mass spectrometry. The solid-state structures of alkynyl complexes were also analyzed with XRD crystallography. In a dilute CH2Cl2 solution, both alkynyl and isocyanide complexes display a similar weak blue phosphorescence originating from a metal-perturbed 3ILCT state localized on the pincer ligand, but their solid-state emission characteristics differ significantly. The isocyanide complexes exhibit strong bathochromic shifts of emission band maxima compared to those observed in solution, which can be assigned to the formation of aggregates that afford excimers with short Au-Au contacts in the T1 emissive state. Among the neutral alkynyl analogues, two compounds retain essentially solution-like emissions, since their rigid crystalline environment precludes the excited-state transformation required for metal-metal bonding. Only the electron-rich dimethylamino derivative, which crystallizes as loosely packed dimers, exhibits a red-shifted solid-state band, and even this shift is substantially smaller than that of its isocyanide congener. The electronic structure of the complexes has been analyzed using DFT calculations, which corroborate the proposed rationalization of the observed trends in the emission characteristics and the difference in the aggregation behavior between the alkynyl and isocyanide chromophores.

PMID 42883181
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