Drug Database
NI

nitroglycerin (Adesitrin / Deponit / Cordipatch)

✓ Approved

Takeda · Small Molecule · Small Molecule

What is nitroglycerin?

nitroglycerin is a small molecule developed by Takeda. It is approved for therapeutic indications via topical or transdermal.

Drug Profile

Brand NamesAdesitrin, Deponit, Cordipatch
CompanyTakeda
Drug ClassSmall Molecule
RouteTopical, Transdermal
StatusApproved
Sources: ClinicalTrials.gov, Takeda

Therapeutic Indications

nitroglycerin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved

Related Research Articles

PubMedPolymers2026-10-16

Investigation of Piezoresistive Behaviors in TPMS Lattice Structures Produced with MWCNT-Reinforced PLA Filament.

Gündüz Mustafa Ercan ME, Bahçe Erkan E

Although the piezoresistive behavior of conductive polymer composites has been widely studied, the geometry-dependent piezoresistive response of MWCNT/PLA-based TPMS lattice structures produced by fused filament fabrication (FFF) remains insufficiently explored. The primary objective of this study is to comparatively investigate the mechanical, thermal, electrical, and piezoresistive behaviors of Gyroid (G), Diamond (D), and Schwarz Primitive (P) TPMS lattice structures produced using the same material system, constant relative density, and XY printing orientation. For this purpose, a 2 wt.% multi-walled carbon nanotube (MWCNT)-reinforced polylactic acid (PLA) composite filament was fabricated via solvent mixing and used to produce the three TPMS topologies through FFF. Mechanical and electromechanical properties were assessed via Shore D hardness, monotonic compression tests, and in-situ electrical measurements using three independent replicate specimens for each topology (n = 3). The highest hardness was recorded for Diamond (75.6 Shore D) and the lowest for Schwarz Primitive (71.2 Shore D). At 50% compressive strain, compressive stresses were 14.164, 8.777, and 3.152 MPa for Diamond, Gyroid, and Schwarz Primitive, respectively. Specific energy absorption (SEA) values followed the same order at 9.161, 6.149, and 2.917 J g-1. Electrical conductivity and resistivity variations under loading were characterized using the four-probe method, with Diamond exhibiting the highest and Schwarz Primitive the lowest conductivity. Piezoresistive analysis showed that Diamond achieved the highest positive compressive gauge factor (GF) values of 4.74 and 2.74 at 10% and 25% strains, respectively. At 50% strain, Gyroid demonstrated superior sensitivity (GF = 1.66) over Diamond (1.57) and Schwarz Primitive (1.49). Electrical resistance exhibited a monotonic decrease with advancing compressive strain across all topologies, validating a coherent and continuous piezoresistive response under uniaxial compression. These results indicate that Diamond offers the best overall performance in mechanical strength, SEA, and low-to-medium strain sensitivity, while Gyroid is preferable for high-strain sensing. Overall, 2 wt.% MWCNT/PLA-based TPMS structures demonstrate considerable potential for piezoresistive sensor applications.

PMID 42885079
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PubMedPolymers2026-10-16

Effects of Lattice Parameters in Material-Extruded PLA Crank Arms on the Kinematics and Bearing Vibrations of an Inverted Slider-Crank Mechanism.

Sevim Caglar C

This study investigates the kinematic and vibration performance of an inverted slider-crank mechanism incorporating poly(lactic acid) (PLA) lattice crank arms fabricated by material extrusion (MEX). Gyroid, Schwarz-D, X, and 2.5X topologies with 5 and 10 mm cell sizes and nominal infill densities of 25%, 50%, and 75% were compared with aluminum and fully solid PLA reference crank arms. All 25% specimens failed before steady-state operation; comparisons therefore covered 16 configurations at 50% and 75%. Output-link angular acceleration, slider relative linear acceleration, and vibration levels at bearings A0 and B0 were measured. A rigid-body dynamic model solved using the fourth-order Runge-Kutta method provided a theoretical baseline. Increasing nominal infill from 50% to 75% reduced the average angular and linear acceleration root mean square error (RMSE) relative to aluminum by 66.2% and 76.0%, respectively; average bearing vibration reductions were 28.6% and 29.6%. Cell size showed no systematic trend. At 75% nominal infill, X and 2.5X crank arms combined low kinematic deviations and bearing vibration levels with approximately 55% lower mass than aluminum. These findings identify promising PLA lattice configurations for lightweight moving components under the investigated manufacturing and operating conditions.

PMID 42884966
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PubMedJournal of prosthodontics : official journal of the American College of Prosthodontists2026-10-16

Mechanical behavior and weight reduction of titanium frameworks with topology-optimized lattice structures for implant-supported prostheses.

Ozden Safa S, Kayacan Muhammed Esad ME, Salmanpour Farhad F, Camci Hasan H et al.

This study aimed to investigate the mechanical behavior of titanium frameworks with triply periodic minimal surface (TPMS) lattice structures designed for additive manufacturing by topology optimization for complete arch implant-supported fixed dental prostheses. A maxillary model supported by four implants (two posteriorly tilted and two anterior parallel) was virtually modeled using a dental computer-aided design program. Titanium frameworks for complete arch implant-supported fixed dental prostheses, which incorporated three distinct TPMS lattice structures (Schwarz, Diamond, and Lidinoid) with variable cell wall thicknesses, were designed using topology optimization software. A total of 36 optimized framework designs were analyzed by finite element analysis under vertical and oblique loading (200 N) at the canine, premolar, and molar (cantilever) regions. A solid, non-optimized titanium framework was the control group. von Mises stress (MPa), maximum displacement (µm), reaction forces (N), and weight reduction ratios (%) were analyzed. Statistical analyses were performed with ANOVA and Tukey's post hoc test (α = 0.05). All topology-optimized frameworks achieved >30% weight reduction, with the Diamond lattice structure demonstrating the highest reduction of 39.92 ± 2.60 (p < 0.001). Although optimized frameworks exhibited higher displacement and stress values than solid controls because of increased flexibility, the peak stress values (190-210 MPa) remained significantly below the yield strength of titanium. Optimized frameworks generated significantly lower reaction forces than solid controls under canine and premolar loading, indicating an energy-absorbing effect. Topology optimization created a semi-rigid framework that incorporates the shock-absorbing benefits of polymers while maintaining the inherent fracture resistance of metallic alloys. Topology-optimized titanium frameworks provide a clinically viable solution for reducing prosthetic weight and minimizing reaction forces at the abutment interface, particularly in complete-arch rehabilitations.

PMID 42885650
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PubMedThe Journal of chemical physics2026-10-15

Quaternion Dirac-Coulomb-Breit integral transformation for relativistic four-component correlated electronic structure theory.

Oele Martijn M, Majumder Rajat R, Upadhyay Shiv S, Zhang Tianyuan T et al.

High-accuracy correlated four-component relativistic electronic structure methods are typically formulated in terms of integrals over molecular orbitals (MOs). Consequently, an efficient and scalable strategy is required to deal with the complexity of transforming relativistic two-electron integrals from the atomic orbital (AO) to the MO basis. The transformation bottleneck is particularly acute for approaches that include Breit interaction integrals, whose computational and memory demands further exacerbate the transformation cost. To overcome this challenge, we develop a quaternion-based, AO-driven direct integral transformation scheme. The method operates on scalar AO integrals and combines quaternion density-based contractions with direct Cauchy-Schwarz screening to systematically exploit integral locality. As a result, the proposed framework substantially lowers the practical computational scaling and provides an efficient, memory-conscious, and highly parallelizable pathway for the routine inclusion of relativistic Dirac-Coulomb-Breit integrals in large-scale four-component correlated calculations.

PMID 42878345
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PubMedJournal of neuroinflammation2026-10-14

Editorial expression of concern: Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice.

Casili Giovanna G, Lanza Marika M, Filippone Alessia A, Campolo Michela M et al.

PMID 42870296
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PubMedFrontiers in medicine2026-10-14

Radial artery characteristics before and after intra-arterial administration of nitroglycerin and verapamil: an optical coherence tomography study.

Wang Senhu S, Zhou Jia J, He Saiying S, Liu Hao H et al.

Radial artery dimensions before and after intra-arterial vasodilator administration remain incompletely characterized along the vessel. This study used optical coherence tomography (OCT) to assess paired changes in mean lumen diameter. Twelve patients underwent baseline OCT 5 min after limited sheath insertion and post-administration OCT after intra-arterial nitroglycerin and verapamil, before coronary angiography. The full OCT-imaged radial artery span was divided into equal proximal, middle, and distal thirds before selecting anatomically matched analyzable portions. Analysis included 1,482 matched cross-sectional pairs (2,964 frames), with a cumulative matched analyzable length of 1,404.4 mm. Measurements at matched 1-mm intervals were aggregated within patients. Mean lumen diameter was the representative lumen metric; area and volume were supportive measurements. Mean lumen diameter increased from 3.06 ± 0.49 to 3.35 ± 0.56 mm (mean paired change, 0.29 mm; 95% CI, 0.20-0.39; P < 0.001). The mean patient-level relative increase was 9.6%. Mean increases were observed in all three thirds in exploratory analyses. Mean radial artery lumen diameter was greater after intra-arterial nitroglycerin and verapamil than at baseline. https://www.chictr.org.cn/hvshowproject.html?id=270,922&v=1.1, Chinese Clinical Trial Registry (ChiCTR) ChiCTR2500097574.

PMID 42871015
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