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COVID-19 vaccine (S 268019 / S268019 / Covgoze)

✓ Approved

Shionogi · Recombinant Proteins · Recombinant Proteins

What is COVID-19 vaccine?

COVID-19 vaccine is a recombinant proteins developed by Shionogi. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesS 268019, S268019, Covgoze
CompanyShionogi
Drug ClassRecombinant Proteins, Vaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Shionogi

Therapeutic Indications

COVID-19 vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsCOVID-19✓ Approved

Related Research Articles

PubMedMilitary medicine2026-10-16

The Case for Dedicated Vaccine Communication Training: A Survey of Military Pediatricians.

Auvil Daley D, Jones Katherine K, Ratusnik Rebecca R, Adams Daniel J DJ

Vaccine uncertainty is rising among families in the United States, even among military families. The ACGME mandates that pediatric residents be trained in effective communication strategies for patients and families hesitant about recommended vaccinations, yet few validated curriculum tools exist. We aimed to understand the current landscape of vaccine uncertainty experienced by military general pediatricians and see what communication strategies were routinely being implemented in clinical practice. In March 2025, 45 graduates of a mid-sized military pediatrics residency program from the years 2016-2024 who were currently practicing general pediatricians were invited to participate in a survey on vaccine communication in clinical practice. The survey was a mix of quantitative questions asking for experienced trends in vaccine uncertainty as well as open-ended questions about communication strategies being implemented. Three clinical researchers performed a manual thematic analysis of free-text answers to understand and quantify common themes. Thirty-seven general pediatricians (82%) responded, and 95% of those surveyed rated a curriculum during medical training on vaccine communication as "very" or "extremely important." Only 19% of physicians were able to recall formal training in addressing vaccine hesitancy during medical school, and only 62% during residency. The 3 most commonly declined vaccines were COVID-19, influenza, and HPV. Pediatricians reported using communication strategies focused on knowledge-sharing (65%), partnership with families (62%), and normalizing vaccines (40%). Common barriers to vaccine acceptance were mistrust and disinterest, most commonly with unwillingness to engage in a conversation. Most practicing military pediatricians who graduated from our residency program report a rise in vaccine uncertainty in their practice and agree that a residency curriculum on vaccine communication is highly important. Such curricula should encourage evidence-based communication styles using vaccine normalization while de-emphasizing the urge to combat misinformation using knowledge-sharing and should specifically address the most commonly declined immunizations.

PMID 42885154
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PubMedWorld journal of pediatrics : WJP2026-10-16

Associations between parental generative artificial intelligence health-advice use and child vaccination uptake in Japan: an exploratory cross-sectional study.

Imanishi Yousuke Y, Iorini Maria M, Jwa Sinchul S, Sakamoto Masahiko M et al.

Parents increasingly use generative artificial intelligence (AI) for health information, but evidence on parental AI use and childhood vaccination is limited. We examined exploratory associations between regular parental AI health-advice use and childhood vaccination in Japan. This cross-sectional study analyzed 2025 nationwide survey data from children aged 1 to 17 years and parents, with a linked 2023-2025 sub-analysis. The exposure was regular parental use of generative AI for health advice at least a few times per month. Outcomes were age-appropriate measles-rubella (MR) vaccination and any mumps, influenza, or coronavirus disease 2019 (COVID-19) vaccination. Modified Poisson regression estimated adjusted prevalence ratios (aPRs) and 95% confidence interval (95% CI) with parent-level clustering and covariates. Among 8282 children and 5170 parents, 1278 (15.4%) had regular AI health-advice users as parents. AI use was not associated with age-appropriate MR vaccination (aPR 1.02; 95% CI 0.97-1.09), but was associated with three vaccines. The adjusted rates were 76.6 versus 72.7% (aPR 1.05, 95% CI 1.01-1.10) for mumps, 56.7% versus 49.0% (aPR 1.16, 95% CI 1.08-1.24) for influenza, 40.6% versus 30.9% (aPR 1.31, 95% CI 1.19-1.45) for COVID-19. The COVID-19 association was strongest among parents younger than 30 years (aPR 2.58; 95% CI 1.90-3.50; P for interaction < 0.001). In the linked sub-analysis, these associations persisted after adjustment for an available 2023 household-level prior vaccination marker and attitudes. Regular parental use of generative AI for health advice was associated with mumps, influenza, and COVID-19 vaccination, but not with age-appropriate MR vaccination. These exploratory, cross-sectional findings are observational associations. They may reflect digital health engagement, health information seeking, socioeconomic differences, or favorable attitudes, rather than vaccine-specific AI advice.

PMID 42881346
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PubMedFoods (Basel, Switzerland)2026-10-16

Korean Temple Food as Plant-Based Food Culture: A Social Big Data Analysis of Changing Online Food Discourse Across the COVID-19 Transition.

Kang Changkyun C, Han Jangheon J

This study examines how Korean-language online discourse surrounding Korean temple food evolved across the COVID-19 transition, with particular attention to its changing meanings as a traditional plant-based food culture. A cleaned corpus of 24,353 online documents was analyzed across three three-year periods: pre-COVID-19 (1 January 2017-31 December 2019), COVID-19 (1 January 2020-31 December 2022), and post-endemic (1 June 2023-31 May 2026). Sixty core keywords were selected for each period and examined using frequency analysis, normalized weighted strength (NWS), degree and closeness centrality, semantic network analysis, CONCOR, and Jaccard similarity. Before COVID-19, discourse centered on vegetarianism, cooking, ingredients, dining, and traditional Buddhist food culture. During the pandemic, veganism, nature, health, and healing became more prominent, strengthening associations with plant-based and health-oriented eating. In the post-endemic period, this food identity remained visible while experiential, wellness-related, and media-driven meanings became more distinct. Jaccard similarity was 0.739 for the pre-COVID-19 versus COVID-19 comparison, 0.600 for COVID-19 versus post-endemic, and 0.519 for pre-COVID-19 versus post-endemic, indicating substantial continuity alongside greater compositional differentiation across more temporally distant comparisons and supporting an interpretation of gradual reconfiguration rather than abrupt change. Overall, Korean temple food has been recontextualized as a broader plant-based food culture in which its traditional Buddhist culinary foundations coexist with health, wellness, experiential consumption, and cultural meanings within contemporary online food discourse.

PMID 42883497
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PubMedBMC public health2026-10-16

COVID-19 among people with intellectual disability in comparison to the general population: diagnoses, hospitalizations, deaths, and vaccinations (IDcare).

Sandberg Magnus M, Kristensson Jimmie J, Axmon Anna A

People with intellectual disabilities (ID) were identified as one of the vulnerable groups during the COVID-19 pandemic. However, few studies have investigated a comprehensive set of COVID-19-related outcomes. The aim of this study is therefore to describe COVID-19-related diagnoses, hospitalizations, deaths, and vaccinations among people with ID compared to the general population. This register-based cohort study included all people living in Skåne, Sweden, on January 1st, 2014. People with ID and still alive January 1st, 2020, constituted the ID cohort (n = 14 046). Those remaining after excluding people in the same family/household comprised the general population cohort (gPop, n = 1 157 138). Data regarding outcomes were collected from Swedish national and regional registers for 2020 and 2021. People in the ID cohort had higher risk of being diagnosed with COVID-19 but were less likely than those in the gPop cohort to have the diagnosis confirmed by laboratory test. Adults and older people in the ID cohort had higher COVID-19 related healthcare utilization in terms of physical primary care visits in 2020 and hospitalizations in both 2020 and 2021, with some sex and age differences within the ID cohort. Among those with at least one physical primary care contact, adults and older women in the ID cohort had fewer contacts in 2020 compared to their peers in the gPop cohort. Where the number of observations allowed for analyses, people in the ID cohort had higher risk of death from COVID-19 than those in the gPop cohort. People with ID had similar healthcare utilization as the general population during the COVID-19 pandemic, with the same or higher levels of COVID-related healthcare, and similar vaccination rates. However, people with ID with healthcare contacts had fewer contacts and bed days and higher mortality. Overall, the Swedish COVID-19 strategy regarding vaccination and healthcare prioritization for people with ID seems to have worked as intended.

PMID 42881375
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PubMedHealthcare (Basel, Switzerland)2026-10-16

Changes in Physical Activity and Psychological Status in Patients with COPD Between Pre- and Post-COVID-19 Assessments: A Pilot Observational Longitudinal Cohort Study.

Alvarez Beatriz Enrich BE, Bravo Marta Ortega MO, Barberà Eva Artigues EA, Machado Leonardo L et al.

Background/Objectives: Physical activity is a key prognostic factor in chronic obstructive pulmonary disease (COPD), but changes in physical activity patterns during the COVID-19 pandemic remain insufficiently characterized. Methods: We conducted an observational longitudinal cohort study in patients with COPD managed in primary care in Lleida, Spain. Baseline assessment was performed between December 2018 and February 2019 (pre-COVID-19 pandemic), and follow-up assessment was conducted between March and June 2021 (post-COVID-19 pandemic). Physical activity was measured using triaxial accelerometry, and clinical, functional, and psychological variables were collected. Results: Of the 192 screened patients, 13 patients were included in the baseline pre-COVID-19 cohort, of whom 7 completed the longitudinal follow-up assessment in the post-COVID-19 period. Among the seven patients with longitudinal follow-up, at baseline, participants exhibited a predominantly sedentary profile, spending approximately 80% of their time in a sedentary mode and accumulating a mean of 6179 steps/day. In the post-COVID-19 period, sedentary time increased to 85.7% and mean steps/day decreased to 3038. Patients also showed a worse psychological profile, mainly driven by increased anxiety levels. Exploratory analyses suggested variable associations between physical activity and clinical, health-related quality of life, and psychological measures. Conclusions: In this small exploratory longitudinal cohort, lower physical activity and a less favorable psychological profile, particularly regarding anxiety, were observed at the post-COVID-19 assessment compared with the baseline. Given the small, paired sample and observational design, these findings should be considered exploratory and hypothesis-generating. Further studies with larger controlled longitudinal cohorts are warranted to confirm these observations.

PMID 42881582
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PubMedNature communications2026-10-16

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19.

Garcia-Prieto Carlos A CA, Musulen Eva E, Grases Daniela D, Davalos Veronica V et al.

Severe Coronavirus disease 2019 (COVID-19) can induce progressive diffuse alveolar damage (DAD) leading to fatal outcomes. Here, we leveraged data from Visium spatial transcriptomics for COVID-19 and control lung samples to unravel insights into cellular and molecular events driving lethal COVID-19. We report a progressive loss of endothelial cell types, pneumocytes type I and natural killer cells coupled with a continuous increase of myeloid and stromal cells, mostly peribronchial fibroblasts, across acute and proliferative DAD. Spatial organization analysis also identified specific compartmentalization including immune-specific clusters across DAD patterns. Importantly, spatially informed ligand-receptor interaction analysis revealed intercellular communication signatures defining COVID-19 induced DAD. Transcription factor activity enrichment analysis identified the TGF-β pathway as DAD driver, highlighting the antagonizing roles of SMAD3 and SMAD7 activity during fibrosis. Integration of these data yielded a signaling kinase pathway in peribronchial fibroblasts with amenable novel targets. Finally, spatio-temporal trajectory analysis characterized an alveolar epithelium regeneration program.

PMID 42881179
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