Drug Database
BF

BF-611 (Turkadon / heparin, LMW, Fidia)

✓ Approved

Fidia · SERPINC1

What is BF-611?

BF-611 is a therapeutic agent developed by Fidia. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesTurkadon, heparin, LMW, Fidia
CompanyFidia
Molecular TargetSERPINC1, F2, F10
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Fidia

Mechanism of Action

Molecular Targets

BF-611 acts on 3 molecular targets:

SERPINC1serpin family C member 1 (ATIII, AT3D)
F2coagulation factor II, thrombin (THPH1, PT)
F10coagulation factor X (FXA, FX)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

BF-611 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved

Related Research Articles

PubMedFrontiers in public health2026-09-20

Factors and a configurational pathway associated with lower turnover intention among high-level medical professionals in county-level hospitals in China: a multicenter cross-sectional study.

Dong Shuxin S, Tai Qiuyuan Q, Yao Yiming Y, Shen Junlong J et al.

This study developed a context-specific framework of perceived conditions related to lower turnover intention among high-level medical professionals in county-level hospitals and examined the configurational pattern associated with a high retention-oriented score. A multicenter cross-sectional study combined three Delphi rounds, psychometric evaluation, and fuzzy-set qualitative comparative analysis (fsQCA). The Delphi process progressed from 33 items in round 1-37 in round 2 and 34 assessed in round 3, with 33 retained for the survey. From July 2024 to February 2025, online and paper questionnaires were distributed in 10 county-level public hospitals in Jiangsu Province. Of 635 questionnaires distributed, 611 were returned and 579 were valid. The sample was randomly split for exploratory factor analysis (EFA; n = 289) and confirmatory factor analysis (CFA; n = 290). fsQCA used the full sample, a frequency threshold of 10, consistency of 0.85, and proportional reduction in inconsistency (PRI) of 0.70. Thirty experts participated in Delphi round 1 and 29 in rounds 2 and 3 after one expert retired. The final 31 condition items showed high internal consistency (alpha = 0.971), suggesting both reliability and possible redundancy. Parallel analysis in the EFA half-sample suggested two factors, whereas a theory-constrained five-factor solution remained interpretable. In the CFA half-sample, the correlated five-factor model fit was marginal (Satorra-Bentler chi-square = 1350.48, df = 424, CFI = 0.903, TLI = 0.893, RMSEA = 0.087, 90% CI 0.082-0.092, SRMR = 0.042) and was similar to the second-order and bifactor models. No condition met the 0.90 necessity threshold. The corrected truth-table analysis identified one high-score configuration, PD*IES*CIS*OIE (consistency = 0.953; PRI = 0.917; coverage = 0.631). PD and CIS were core present conditions; IES and OIE were peripheral present conditions; IEPS was not included. A single sufficient configuration combined favorable perceptions of personal development, institutional/environmental support, compensation/incentive support, and organizational/interpersonal empowerment. The result does not support multiple substitutable pathways. Because the outcome was a retention-oriented score derived from a turnover-intention measure, the findings concern lower turnover intention rather than directly observed retention. The cross-sectional, individual-level results indicate associations and should not be interpreted causally or at the hospital level.

PMID 42763469
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PubMedFrontiers in psychology2026-09-20

The association between habitual emotion regulation, childhood adversity, and cluster C personality disorders symptomatology.

Crişan Ştefania M ŞM, Miu Andrei C AC, Szentágotai-Tătar Aurora A

The mechanisms linking childhood adversity and cluster C personality disorders (PDs) remain unclear. Available research points to emotion regulation as a possible mechanism. Emotion regulation difficulties are documented in the case of cluster C, but studies focus on strategy implementation, while regulation goals received less attention. This study aimed to examine the associations between childhood adversity, emotion regulation goals and strategies, and cluster C PDs. Furthermore, we explore the moderating role of childhood maltreatment in the association between emotion regulation and cluster C. This cross-sectional study employs a sample of 141 adults from the Romanian community (aged 18-55 years; M = 27.31, SD = 9.13). We employed instruments assessing facets of childhood adversity (CTQ, QUIC, MSPSS, CTSPC, RFQ, and the MacArthur Scale of SES), emotion regulation goals (ERGS) and strategies (E-ERQ), cluster C symptoms (SNAP-2) and associated personality dysfunction (LPFS-BF). Main analyses suggest significant associations between avoidant PD and total QUIC scores (r = 0.206, p ≤ 0.05) and total MSPSS scores (r = -0.206, p ≤ 0.05). Instrumental goals correlated positively with both avoidant PD (r = 0.337, p ≤ 0.001) and dependent PD (r = 0.339, p ≤ 0.001). Reappraisal showed negative correlations with avoidant PD (r = -0.224, p ≤ 0.05) and dependent PD (r = -0.219, p ≤ 0.05). Avoidant PD was also correlated with suppression (r = 0.336, p ≤ 0.001) and selective attention (r = 0.203, p ≤ 0.05). Obsessive-compulsive PD was correlated with situation selection (r = 0.200, p ≤ 0.05). Importantly, childhood maltreatment moderated the association between hedonic goals and obsessive-compulsive PD. Sensitivity analyses were conducted to account for deviations from assumptions in the main analysis. Findings highlight the increased use of instrumental goals, suppression, situation selection, selective attention (which could entail disengagement from emotions), and reduced use of reappraisal. Taking the interplay between childhood adversities and emotion regulation difficulties in the case of cluster C into account could expand future literature, which may contribute to the improvement of assessment, prevention, and intervention efforts for cluster C symptoms, especially when exposure to childhood adversities is present.

PMID 42763441
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PubMedInternational journal of pharmaceutics2026-09-19

Integrating a multistage DoE strategy using Plackett-Burman screening and Box-Behnken optimization to develop cefuroxime transfersomal patch for diabetic ulcer biofilm eradication.

Afrose Naureen N, Rajendran Kavitha K

Biofilm (BF)-forming S. aureus and P. aeruginosa are present in Diabetic ulcers (DUs) showing high tolerance to conventional antibiotics. Cefuroxime (Cef) exhibits strong activity but low skin permeability and low BF penetration. To design and develop a Cef loaded-transfersomal patch for better topical delivery and BF eradication in DUs. 11 variables were screened by Plackett-Burman design (12 runs) and five variables found to be critical were optimized by Box-Behnken design (46 runs). Transfersomes were optimized and embedded in HPMC K5 patches. Characterization included size, PDI, zeta potential, entrapment efficiency, deformability index, FTIR, DSC, ex-vivo permeation, and stability. Anti-BF activity was determined by MBEC, time-kill activity and crystal violet assay. The optimized formulation yielded transfersomes with mean size 178.3±4.8 nm (PDI 0.28±0.01), zeta potential -34.3±0.7 mV, entrapment efficiency 79.3±0.6%, deformability index 4.5±0.1, and 24 hrs drug release 77.7±1.6%. Patches showed an even thickness, folding endurance >175, drug content 86.6%, and cumulative skin permeation 136 μg/cm2 (≈12.6% of load). Amorphous drug dispersion was confirmed by DSC. Importantly, the patch was effective in reaching MBEC values of 21 μg/ml and 45 μg/ml respectively against S. aureus and P. aeruginosa in 8-12 hrs, which represents ≥3 log10 reduction. BF mass reduction was observed by crystal violet assay. The accelerated stability showed no significant difference in the critical quality attributes. This patch platform with transferosomal technology significantly improves the skin permeation of Cef and the eradication of BF, offering new therapeutic possibilities for the treatment of DUs linked with BF.

PMID 42763077
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PubMedJournal of applied physiology (Bethesda, Md. : 1985)2026-09-19

Diminished sympathoinhibition during the onset of low-intensity leg cycling in young Black males.

Katayama Keisho K, Oldham Zachary R ZR, Taherzadeh Ziba Z, Alhalimi Taha A TA et al.

Previous studies have reported that non-Hispanic Black males exhibit augmented blood pressure (BP) responses to dynamic exercise relative to White males; however, the underlying mechanism(s) remain unclear. To our knowledge, no studies have examined the muscle sympathetic nerve activity (MSNA) response to dynamic exercise in BL adults. The purpose of this study was to examine potential racial differences in the sympathoinhibition that occurs at the onset of dynamic exercise. We hypothesized that cardiopulmonary baroreflex-mediated inhibition of sympathetic vasomotor outflow during the onset of low-intensity dynamic exercise is diminished in BL individuals. MSNA was recorded via microneurography of the left radial nerve in nine non-Hispanic Black (BL; 20±3 years, mean±SD) and eleven non-Hispanic White (WH; 22±4 years) males. BP was measured by finger photoplethysmography, which was verified by automated brachial BP measures. Participants performed 3 minutes of bilateral leg cycling at 15 watts on a cycle ergometer in the 70-degree semirecumbent position. MSNA burst frequency (BF) decreased during cycling in both groups; however, the decrease was significantly smaller (P<0.001) in the BL group (-4.7±3.7 bursts/min) than in the WH group (-11.3±5.0 bursts/min). Mean BP increased during cycling in both groups, with no significant difference between the two groups (BL, +7.4±4.2 vs. WH, +6.9±7.1 mmHg, P=0.958). These findings suggest that cardiopulmonary baroreflex-mediated inhibition of sympathetic vasomotor outflow at the onset of dynamic exercise is diminished in BL males compared to WH males.

PMID 42762482
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PubMedBJPsych open2026-09-18

Revised long version (KEZ-R) and short form (KEZ-S) of the Cologne Questionnaire on Attitudes towards Coercive Measures in in-patient mental healthcare.

Schmitz-Buhl Mario M, Baar Immanuel I, Gouzoulis-Mayfrank Euphrosyne E

Attitudes of mental health professionals towards coercive measures are crucial with respect to both the application of these methods and efforts to reduce coercion in psychiatric care. Existing instruments primarily assess cognitive aspects, often neglecting emotional and contextual dimensions. The Cologne Questionnaire on Attitudes towards Coercive Measures (KEZ) addresses these gaps but has so far only been available in German and in a relatively long format. To revise the KEZ for international use and develop and validate a short version suitable for both research and clinical practice. The revised version was intended to ensure a balanced representation of different coercive measures. A revised long version (KEZ-R) was developed and administered via an anonymous online survey to 611 mental health professionals from Germany and German-speaking Switzerland. Psychometric properties of the German version were analysed using factor and reliability analyses. A short form (KEZ-S) was derived on the basis of theoretical and content-related criteria. The 40-item KEZ-R replicated the original three-factor structure of the KEZ and showed good reliability (Cronbach's α = 0.87). The 15-item KEZ-S demonstrated strong correlation with the long version and acceptable overall reliability (α = 0.67). Both versions captured cognitive, emotional and interactional aspects of attitudes towards coercive measures. The KEZ-R and KEZ-S are reliable instruments for assessment of attitudes towards coercive measures in psychiatric settings. Although validation was conducted in German, the availability of an English translation supports international use and future validation studies.

PMID 42757609
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PubMedRespirology case reports2026-09-17

Rescue Diagnosis of Upper-Lobar Station 12U Lymph Nodes Using the Thin Convex-Probe EBUS Bronchoscope (BF-UCP190F): A Report of Two Cases.

Kitano Toki T, Takigawa Yuki Y, Sato Ken K, Goda Mayu M et al.

BF-UCP190F (Olympus) is a newly developed thin convex-probe endobronchial ultrasound (TCP-EBUS) bronchoscope, improving access to distal bronchi. We report two cases in which TCP-EBUS enabled successful endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) of the upper-lobar station 12U lymph node (#12U LN) via B3 after conventional bronchoscopic forceps sampling failed to provide a definitive diagnosis. In the first case, forceps biopsy of a left upper lobe tumour was non-diagnostic; TCP-EBUS-guided EBUS-TBNA of the left #12U LN established lung adenocarcinoma with N1 involvement. In the second case, the initial bronchoscopy yielded only cytological evidence of carcinoma without histological confirmation; TCP-EBUS-guided sampling of the right #12U LN revealed metastatic small cell carcinoma. In both cases, the pathological diagnosis of EBUS-TBNA guided subsequent treatment. These cases suggest that BF-UCP190F expands the diagnostic range of bronchoscopy and may serve as a valuable rescue technique for sampling upper lobar hilar lymph nodes in clinical practice.

PMID 42751719
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