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AM

amorolfine

✓ Approved

Galderma SA · Small Molecule · Small Molecule

What is amorolfine?

amorolfine is a small molecule developed by Galderma SA. It is approved for therapeutic indications via topical.

Drug Profile

CompanyGalderma SA
Drug ClassSmall Molecule
RouteTopical
StatusApproved

Therapeutic Indications

amorolfine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsWound infection fungal✓ Approved

Related Research Articles

PubMedThe Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons2026-09-19

NEGLECTED SEYMOUR FRACTURES OF THE HALLUX IN CHILDREN: FIXATION VERSUS NO FIXATION, AND TRANSARTICULAR VERSUS EXTRA-ARTICULAR TECHNIQUE.

Demir Ibrahim Halil IH, Gonder Nevzat N, Unat Beytullah B, Erol Ramazan R et al.

Open Seymour fractures of the hallux, distinct from closed physeal injuries, lack a clear optimal stabilization strategy when presentation is delayed. To compare reduction maintenance and recovery of interphalangeal (IP) motion after three operative strategies for neglected, open hallux Seymour fractures. Retrospective comparative cohort study. Forty-four children presenting more than 48 hours after injury underwent irrigation, debridement, and nail bed repair, with transarticular fixation (TFx, n=16), extra-articular crossed-wire fixation (EFx, n=17), or no skeletal fixation (NoFx, n=11). Minimum follow-up was 12 months. Categorical outcomes were compared with exact tests; continuous outcomes with Kruskal-Wallis tests and adjusted pairwise comparisons. Loss of reduction occurred in 5/11 NoFx patients versus 0/33 fixed patients (p < 0.001). Median time to full IP motion was 77 days in TFx versus 56 days in both EFx and NoFx (TFx vs EFx, p = 0.002 after adjustment). Physeal alteration occurred in 3/16 TFx, 3/17 EFx, and 7/11 NoFx patients (overall p = 0.027), though pairwise comparisons were not significant. All 5 patients with loss of reduction had physeal alteration, versus 8/39 without (exploratory p = 0.001). Osteomyelitis occurred in 12/44 patients and correlated with longer treatment delay. Fixation was associated with maintained reduction in this neglected, open-injury cohort. Extra-articular fixation showed earlier recovery of full IP motion than transarticular fixation, with no loss of reduction in either fixed group. These findings support joint-sparing fixation when feasible but do not establish causal superiority or identify which fractures may safely remain unfixed. Level III, retrospective comparative study.

PubMedJournal of orthopaedic trauma2026-09-18

Transport Intramedullary Nail for Nonunion.

Crist Brett D BD, Lee Mark A MA

Nonunions with bone defects create technical challenges for fracture healing. All-internal bone transport with an intramedullary nail offers benefits over the other bone segment transport options including being simpler for the patients, avoiding the associated soft tissue issues that externally based implants or techniques and minimizing residual deformity by maintaining the anatomical axis along the intramedullary nail. This article reviews preoperative planning, technical tricks and specific techniques for internal bone transport, including the corticotomy, distraction, docking site and regenerate management, and the available literature.

PubMedJournal of orthopaedic trauma2026-09-18

Intramedullary Bone Transport Nail for the Treatment of Segmental Tibial Bone Defect After Acute Traumatic Bone Loss.

Scolaro John A JA

Medullary bone transport is a valuable technique to perform distraction osteogenesis with all-internal components. This technique has notable advantages over other techniques which rely on external pins, wires, and frames. Preoperative templating and surgical planning are critical to the success of this procedure to ensure that movement of the segment across the defect can be performed based on the specifications of the nail. The case of a young patient with a 67 mm diaphyseal tibial defect after an open tibial shaft fracture who had successful reconstruction with a medullary bone transport nail is presented.

PubMedThe Annals of thoracic surgery2026-09-18

Another Nail In The Coffin for Ex Vivo Heart Perfusion?

Teimouri Dereshgi Amir A, Chin Clifford W CW, Shah Ashish S AS, Bommareddi Swaroop S et al.

PubMedJournal of orthopaedic trauma2026-09-18

New Technology for the Treatment of Bone Defects and Limb Length Discrepancies with a Motorized Intramedullary Bone Transport Nail.

Frumberg David B DB, Vasudevan Rajiv S RS, Wellings Elizabeth P EP

Bone defects are among the most challenging problems treated by limb reconstruction surgeons and orthopaedic traumatologists. Bone transport is a biological reconstruction technique which harnesses distraction osteogenesis to create new bone in critical bone defect. This technique has been successfully performed with a variety of internal and external solutions. This work introduces a newly available technology which provides a fully implantable, all-internal solution (eg, without the need for external fixation) for bone transport with the option to simultaneously address residual limb length discrepancy.

PubMedJournal of chromatography. A2026-09-18

Robust graphene oxide composite aerogel for micro solid-phase extraction of methorphan enantiomers from biological matrices.

Zhang Chunxiao C, Li Xiaoyang X, Huang Shaojing S, Xu Zhongshi Z et al.

Methorphan exists as two optically active enantiomers, levomethorphan (LVM) and dextromethorphan (DXM). DXM is a widely utilized central antitussive, whereas LVM is a strictly regulated controlled substance. This study established a method combining micro-solid-phase extraction with enantioselective high-performance liquid chromatography-mass spectrometry (LC-MS) for the simultaneous determination of LVM and DXM in human urine and nail samples. A spherical porous graphene oxide composite aerogel (GO@CNF/CMC) served as the extraction sorbent. It was synthesized by covalently crosslinking graphene oxide (GO), cellulose nanofibers (CNF), and carboxymethyl chitosan (CMC) via a combined sol-gel and dropwise addition strategy. Aerogels with various GO mass fractions were fabricated for sorption optimization. With a maximum GO loading of 11.2 wt%, the aerogel delivered superior extraction efficiency owing to its large specific surface area and synergistic intermolecular interactions including hydrogen bonding, π-π stacking and electrostatic attraction. The aerogel exhibited excellent mechanical stability and recyclability, with nearly consistent extraction efficiency over 15 extraction cycles. Under optimized extraction conditions, the method exhibited good linearity in the range of 0.05-10 μg/L. The limits of detection were 0.01 μg/L for both LVM and DXM. The spiked recoveries in urine and nail samples ranged from 81.6% to 108.4%, and matrix effects ranged from 83.3% to 105.7%. This method provides a facile, rapid, green and sensitive analytical strategy for the trace analysis of methorphan enantiomers in complex biological matrices.

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