Drug Database
CT

CTC-111 (Anact C)

✓ Approved

Meiji Holdings · PROC

What is CTC-111?

CTC-111 is a therapeutic agent developed by Meiji Holdings. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAnact C
CompanyMeiji Holdings
Molecular TargetPROC
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Meiji Holdings

Mechanism of Action

Molecular Targets

CTC-111 acts on 1 molecular target:

PROCprotein C, inactivator of coagulation factors Va and VIIIa (APC, PROC1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

CTC-111 is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved
Skin and subcutaneous tissue disordersPurpura fulminans✓ Approved

Related Research Articles

PubMedAnalytical chemistry2026-07-17

Unraveling CTC Heterogeneity: DLD-Assisted Immunomagnetic Sorting and ICP-MS for the Isolation and Profiling of Epithelial-Mesenchymal Transition-Related States.

Ma Junrong J, He Man M, Chen Beibei B, Yuan Guolin G et al.

Accurate analysis of circulating tumor cell (CTC) heterogeneity at the single-cell level, in addition to circulating tumor cell (CTC) enumeration, holds great promise for advancing our understanding of cancer progression and therapeutic response. Magnetic-activated cell sorting integrated with microfluidics has emerged as a powerful tool for CTC isolation and phenotyping. However, this method is still plagued by inherent trade-offs among sample throughput, magnetic separation resolution, and recovery of CTC subpopulations for downstream analysis. To address these limitations, we report a DLD@MACS chip engineered to generate a magnetic field gradient within a deterministic lateral displacement (DLD) channel, which facilitates the simultaneous size-based enrichment of CTCs and magnetic separation of their epithelial cell adhesion molecule (EpCAM) expression-related phenotypes into distinct streams, including the separation and recovery of EpCAM-negative CTCs. The DLD@MACS chip enabled significantly higher sample throughput (200 μL/min) compared to reported MACS-based phenotyping methods. Furthermore, a synergistic effect between DLD and the magnetic field gradient yields an enhanced separation resolution even at low magnetization. Through single-cell inductively coupled plasma mass spectrometry (SC-ICP-MS) detection, this method was successfully applied to enumeration and phenotyping of CTCs in the blood samples from more than 30 breast cancer patients. The detected CTC number and relative EpCAM expression were correlated to the breast cancer stage and clinical treatment, demonstrating the promising clinical applicability of this method.

PMID 42464483
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PubMedEuropean journal of cancer (Oxford, England : 1990)2026-07-17

Organotropism-specific circulating tumor cells profiles: Morphology and heterotypic clustering predict metastatic sites in liquid biopsy of solid tumors.

De Meo Michela M, Siringo Marco M, Gandini Orietta O, Gareri Roberta R et al.

While circulating tumor cells (CTCs) are the primary drivers of metastatic dissemination, the mechanisms governing their organotropism remain poorly characterized. CTC morphology, including size and elongation, and cluster configuration (homotypic vs. heterotypic) may encode site-specific metastatic signatures. Characterizing these features could provide critical pre-radiological biomarkers for predicting organ-specific recurrence and refining metastatic risk assessment in clinical. We analyzed a large retrospective cohort of patients with a single metastatic site (bone, liver, brain, or lung), regardless of primary tumor origin, using the CellSearch® system. CTC were classified by morphological subtypes (canonical, large, elongated) and cluster phenotypes (homotypic versus heterotypic). CellSearch® profiling of 8359 CTCs from 82 patients with metastatic cancer uncovered marked site-specific heterogeneity reflective of tumor burden and biological tropisms. Among 34 patients with bone metastases, 7010 CTCs (median 21 [IQR 6-135]) were predominantly canonical (85%) and organized in nearly exclusive homotypic clusters (97.7%). In 26 patients with liver metastases, 1273 CTCs (median 4 [IQR 3-7]) shifted to large CTCs (80%) with mixed homotypic (65.2%) and heterotypic (34.8%) clustering. Conversely, 22 patients with brain/lung metastases yielded 76 CTCs (median 3 [IQR 3-5]), enriched for elongated forms (84%) in exclusively heterotypic clusters (100%). These distinct profiles demonstrated statistically significant disparities (P < 0.001), implicating anatomical and microenvironmental drivers of CTC shedding and dissemination. CTC morphology and heterotypic clustering exhibit organotropism-specific profiles, aligning with microenvironmental cues like capillary shear, endothelial activation, and immune niches. These findings position multimodal CTC analysis as a liquid biopsy tool for early metastasis site forecasting, guiding precision interventions.

PMID 42462627
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PubMedRSC advances2026-07-17

Molecularly imprinted polymer ZnO nanostructures derived from Pseuderanthemum palatiferum leaf extract for paper-based colorimetric sensing of chlortetracycline.

Nghia Nguyen Ngoc NN, Ton Tran Anh TA, Hung Cao Phat CP, Khang Hoang Xuan HX et al.

Chlortetracycline (CTC) is a widely used tetracycline antibiotic in veterinary medicine, livestock production, and aquaculture, yet its excessive use and environmental persistence have raised increasing concerns regarding food safety, ecological contamination, and antibiotic resistance. In this study, we developed a portable and selective colorimetric sensing platform based on molecularly imprinted ZnO nanozymes integrated into a paper-based analytical device (PAD) for rapid on-site detection of CTC. ZnO nanoparticles (ZnO NPs) were synthesized via a green route using Pseuderanthemum palatiferum (P. palatiferum) leaf extract and subsequently surface-imprinted using 3-aminopropyltriethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) in the presence of CTC as the template molecule. Structural characterization by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) confirmed the successful formation of the imprinted polymer layer while preserving the hexagonal wurtzite crystalline structure of ZnO. The resulting molecularly imprinted polymer-modified ZnO (MIP@ZnO) retained intrinsic peroxidase-like activity and efficiently catalyzed the H2O2-mediated oxidation of 3,3',5,5'-tetramethylbenzidine (TMB), generating a blue oxidized product with a characteristic absorbance at 652 nm. Upon selective rebinding of CTC to the imprinted cavities, the catalytic activity was suppressed through a binding-induced inhibition mechanism, resulting in a concentration-dependent decrease in absorbance. Under optimized conditions, the sensor exhibited a linear response over the range of 0-15 µM with a limit of detection (LOD) of 0.35 µM. Integration into a capillary-driven PAD enabled rapid visual analysis within minutes with minimal reagent consumption and no need for complex instrumentation. The platform also demonstrated good selectivity against structurally related antibiotics and common interfering species. Practical applicability was verified using tap water and milk samples, affording satisfactory recoveries and acceptable precision without extensive sample pretreatment. These results demonstrate that the proposed MIP@ZnO-based PAD provides a low-cost, field-deployable, and effective strategy for selective monitoring of CTC residues in complex real samples.

PMID 42466465
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PubMedLangenbeck's archives of surgery2026-07-17

Anatomical dissection approaches in right hemicolectomy with complete mesocolic excision: characteristics of surgical outcomes from a systematic review and Bayesian network meta-analysis.

Kitaguchi Daichi D, Forgione Antonello A, Innocenzi Chiara C, Yang Yuchuan Y et al.

Several anatomical dissection approaches have been proposed for right hemicolectomy (RHC) with complete mesocolic excision (CME). Even though all are considered safe, the evidence-based guiding selection remains limited. We aimed to systematically review the literature and perform a Bayesian network meta-analysis to compare their relative characteristics. A comprehensive search of PubMed, Embase, and the Cochrane Library was completed through August 2025. Eligible studies included adult patients undergoing minimally invasive RHC with CME, with the predominant dissection direction defined as medial-to-lateral (MtL), lateral-to-medial (LtM), cranial-to-caudal (CtC), or caudal-to-cranial, also known as the bottom-to-up (BtU) approach. The primary outcome was the number of harvested lymph nodes (LNs). Secondary outcomes included operative time, blood loss, and conversion to open surgery. Fourteen studies including 2,947 patients were analyzed (MtL: 1,539; LtM: 401; CtC: 291; BtU: 716). No significant pairwise differences were observed in lymph node harvest, although ranking analysis indicated that BtU was the most favorable approach. Secondary outcomes did not show any significant differences, although BtU tended to reduce operative time as compared to MtL. LtM ranked worst and was associated with a significantly higher open conversion rate versus BtU (RR: 26.84, 95% CrI: 2.29-2014.36) and MtL (RR: 8.27, 95% CrI: 1.07-216.68). No significant differences in LN harvest were observed among the four approaches. The BtU approach showed a non-significant trend toward a shorter operative time, whereas LtM was associated with a significantly higher rate of conversion to open surgery. Overall, the available evidence does not demonstrate clear superiority of any single approach, and further prospective studies are needed to confirm these findings.

PMID 42463590
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PubMedNature communications2026-07-17

Intermetallic Pt3In concave tetrahedra for oxygen reduction electrocatalysis in proton exchange membrane fuel cells.

Yu Wenhe W, Li Menggang M, Li Lu L, Wu Xiaowen X et al.

Scaling proton exchange membrane fuel cells (PEMFCs) demands efficient and durable electrocatalysts for the cathodic oxygen reduction reaction (ORR). Concave surfaces and intermetallic phases have been proven to promote the activity and stability of Pt-based catalysts, yet integrating these two structural features in one catalyst remains challenging. Herein, we achieve this in a class of intermetallic, concave tetrahedral Pt3In (i-ct-Pt3In), through a sequential Pt(111)-selective wet-chemical etching and indium-enabled morphology-preservable annealing. The i-ct-Pt3In/C catalyst delivers a mass activity of 2.49 A mgPt-1 in acidic media, preserving 97.8% of its activity after 30,000 cycles. In phosphate-containing electrolytes, it achieves a mass activity of 0.3 A mgPt-1, representing a 7.5-fold improvement over commercial Pt/C and translating to a peak power density of 1.0 W cm-2 in a high-temperature PEMFC at 160 °C. Theoretical calculations verify weakened adsorption of oxygenates and phosphate anions on concave Pt3In(111) relative to flat Pt(111), accounting for enhanced ORR kinetics and phosphate tolerance. This work highlights the potential of ordering morphological nanocrystals for energy electrocatalysis.

PMID 42463711
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PubMedJournal of the American Chemical Society2026-07-17

Rational Design of the Composite Perfluoro-Sulfonic Ionomer for High-Performance Proton Exchange Membrane Fuel Cells.

Mao Tingting T, Fan Haiyang H, Liu Youxing Y, Li Qinqin Q et al.

Scaling proton exchange membrane fuel cells (PEMFCs) is constrained by high cathodic overpotential and platinum usage for the oxygen reduction reaction, challenges exacerbated by catalyst poisoning from perfluorosulfonic acid (PFSA) ionomers. Though compositing PFSA with additives can mitigate this poisoning, progress has remained largely empirical due to the lack of quantitative assessment tools. Here, we introduce an electrochemical probe leveraging ionomer-coated single-crystal Pt(111) to quantify the coverage and strength of PFSA adsorption, elucidating how cationic additives suppress Pt poisoning. We identify an inverse correlation between cation hydration energy and PFSA adsorption, guiding the rational design of a poorly hydrated tetramethylammonium-anchored covalent organic framework (TMA+-COFs) as an ionomer additive. Electrochemical and spectroscopic analyses reveal that the composite TMA+-COFs/PFSA layer significantly inhibits sulfonate adsorption and poisoning onto Pt(111) through robust electrostatic interactions, which translates to a 1.7- and 4-fold activity enhancement for industrial Pt/C in rotating-disk and gas-diffusion electrodes, respectively. We also demonstrated a high mass activity of 1.08 A mgPt-1 in a PEMFC cathode with TMA+-COFs. Our work provides an alternative avenue to conventional catalyst engineering through the rational design of advanced composite ionomers for high-performance, low-Pt PEMFCs.

PMID 42463981
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