Drug Database
CT

CTC-111 (Anact C)

✓ Approved

Meiji Holdings · PROC

What is CTC-111?

CTC-111 is a therapeutic agent developed by Meiji Holdings. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAnact C
CompanyMeiji Holdings
Molecular TargetPROC
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Meiji Holdings

Mechanism of Action

Molecular Targets

CTC-111 acts on 1 molecular target:

PROCprotein C, inactivator of coagulation factors Va and VIIIa (APC, PROC1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

CTC-111 is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved
Skin and subcutaneous tissue disordersPurpura fulminans✓ Approved

Related Research Articles

PubMedInternational journal of general medicine2026-08-30

Diagnostic Utility of Extracellular Levels of Serum Amyloid P and Proteoglycan 4: A Case-Control Study in Gestational Diabetes Mellitus.

Zhong Jing J, Wu Heming H, Huang Qiuhong Q, Zheng Zhiyuan Z et al.

Gestational diabetes mellitus (GDM) is linked to excessive inflammatory activation during pregnancy. Serum amyloid P component (SAP) and proteoglycan 4 (PRG4) participate in inflammatory and placental regulatory processes; however, their relationships with GDM remain insufficiently clarified. This exploratory single-center retrospective study aimed to preliminarily investigate the associations of circulating SAP and PRG4 concentrations with GDM. A total of 111 Pregnant women undergoing 24-28 week OGTT screening were enrolled and divided into the GDM group and normal glucose tolerance (NGT) group. Serum SAP and PRG4 levels were measured by ELISA. Baseline characteristics, biomarker concentrations and relevant clinical indices were compared between groups. Receiver operating characteristic (ROC) curve and logistic regression analyses were used to evaluate their associations and predictive value. The median serum levels of proteoglycan 4 (PRG4) and serum amyloid P (SAP) were 1.81 (1.11, 2.60) ng/mL and 308.55 (227.06, 437.02) ng/mL, respectively. The serum SAP level in the GDM group [437.66 (366.69, 543.72) ng/mL] was significantly higher than that in the NGT group [232.22 (203.12, 295.86) ng/mL] (p<0.001). The AUC of SAP for predicting GDM was 0.886 (p<0.001). No significant difference in serum PRG4 levels was found between the two groups (p=0.111), with an AUC of 0.588 (p=0.111). Logistic regression analysis showed that serum SAP level ≥386.88 ng/mL was independently associated with GDM (odds ratio (OR)=3.292, 95% confidence interval (CI): 1.270-8.528, p=0.014); advanced maternal age (≥30 years), history of induced abortion and history of adverse pregnancy were also independent risk factors for GDM. Elevated serum SAP may be correlated with GDM, whereas peripheral PRG4 showed no obvious association with gestational hyperglycemia in this cohort.

PMID 42668852
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PubMedAdvances in medical education and practice2026-08-30

Analysis of Generative Artificial Intelligence Governance in Publicly Available Documentation of Global and Saudi Universities Offering Health Informatics Programs.

Alhur Anas Ali AA, Al-Kahtani Nouf Khalid NK

Generative artificial intelligence (GenAI) has rapidly entered higher education, prompting universities to publish policies and guidance for its responsible use. Little is known about how GenAI is governed within Health Informatics and related programs, or how international and Saudi institutions compare. To analyze and compare publicly available GenAI governance in global and Saudi universities offering Health Informatics and related programs, focusing on policy availability, governance-domain coverage, and gaps. A qualitative document analysis and comparative policy analysis were conducted. Thirty international universities (selected via the QS World University Rankings by Subject 2025) and sixteen eligible Saudi institutions offering Health Informatics, Health Information Management, Digital Health, or related programs were included. Publicly available governance sources-comprising formal policy documents and web-based institutional guidance-were retrieved from official institutional websites between March and May 2026 and analyzed using directed qualitative content analysis across nine governance domains. Inter-coder reliability was almost perfect (Cohen's κ = 0.96), and group comparisons were tested using Fisher's exact test. In total, 117 governance sources met the inclusion criteria (111 international; 6 Saudi). All international universities (30/30) had publicly available GenAI governance, versus six of sixteen Saudi universities (37.5%). International coverage was significantly greater for Transparency and Disclosure (87.4% vs 33.3%; p=0.005), Ethical Considerations (91.9% vs 50.0%; p=0.014), and AI Literacy and Capacity Building (81.1% vs 33.3%; p=0.019). Program-specific Health Informatics governance appeared at only two international institutions and no Saudi universities; clinical-data-governance provisions were absent from all Saudi sources. Based on publicly available documentation, international universities showed broader and deeper GenAI governance than Saudi institutions, with gaps in transparency, AI literacy, ethics, and Health Informatics-specific and clinical-data governance. Strengthening discipline-specific guidance may support responsible GenAI integration and digital-health workforce preparation.

PMID 42668978
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PubMedCureus2026-08-30

Assessment of Knowledge, Attitudes, and Practices Related to the Hall Technique Among Pediatric Dentists in Jordan.

Almaaita Alaa O AO, Alshdefat Areej A, Almaaitah Hind H, Altarawneh Heba H et al.

The Hall technique (HT) manages dental caries in primary molars by sealing the lesion with a preformed metal crown, a minimally invasive strategy aimed at arresting the disease process. Although convincing evidence of efficacy is available, global acceptance varies. This study aimed to evaluate the knowledge, attitudes, and practices (KAP) of Jordanian pediatric dentists regarding the HT and its main features. A cross-sectional study was carried out using an online questionnaire distributed to Jordanian pediatric dentists from November 1 to 30, 2025. The questionnaire surveyed demographics, knowledge (rationale, indications), attitudes (efficiency, evidence-based), and practices (current use, challenges, concerns). Descriptive statistics, chi-square tests, and binomial logistic regression were used to identify predictors of HT implementation among 120 participants. Most respondents were female (103/120, 85.8%) and board-certified (91/120, 75.8%). The rationale for caries arrest by sealing with the HT was understood by 118/120 (98.3%) of the respondents. The frequency of HT use was 104/120 (86.7%). Years of clinical practice were significantly associated with the perception that HT is best for uncooperative patients (p = 0.031), and belief in medical contraindications was associated with reduced HT use (p = 0.024). The main concerns were occlusion (65/120, 54.2%), sealing over caries (54/120, 45.0%), and parental acceptance (54/120, 45.0%). The majority perceived HT as a time-saving method (111/120, 92.5%), and the attitudes were generally positive. Logistic regression analysis revealed that the belief in time-saving (OR = 8.58, 95% CI: 2.09-35.21, p = 0.003) and evidence base (OR = 5.21, 95% CI: 1.37-19.81, p = 0.015) were significant positive predictors for HT use, whereas the concern of parental acceptance (OR = 0.24, 95% CI: 0.09-0.65, p = 0.005) and sealing over caries (OR = 0.34, 95% CI: 0.13-0.89, p = 0.027) were significant negative predictors. The model explained 28.4-45.2% of the variance in HT use and was a good fit (Hosmer-Lemeshow p = 0.342). Pediatric dentists in Jordan had a high level of knowledge of and use of the HT, with adoption rates higher than in many other countries. A positive perception of time efficiency and evidence-based belief strongly favor clinical use, while concerns about parental acceptance and sealing over caries are the main barriers to consistent implementation.

PMID 42669021
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PubMedAnnals of surgical oncology2026-08-29

Liquid Biopsy in Resected Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.

Qian Jiage J, Ceuppens Sebastiaan S, Tirukkovalur Nikhil V NV, He Hong-Zhang HZ et al.

Distinct liquid biopsy modalities are emerging as promising tumor-specific biomarkers to monitor treatment response and predict survival in pancreatic ductal adenocarcinoma (PDAC). Circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs) may reflect underlying systemic disease burden and complement conventional imaging or CA19-9 assessment. This systematic review and meta-analysis evaluated the prognostic significance of liquid biopsy biomarkers in patients with resected PDAC. A systematic review and meta-analysis was performed in accordance with PRISMA guidelines. Studies published until 1 July 2025 evaluating ctDNA, CTCs, or EVs in patients with resected PDAC, with or without neoadjuvant therapy, were evaluated. Primary outcomes were overall survival (OS) and recurrence-free survival (RFS). Study quality was assessed using the QUADAS-2 tool. The meta-analysis included 44 studies (26 ctDNA, 12 CTC, and 6 EV studies; >2,500 patients). Preoperative ctDNA positivity was associated with worse OS (pooled hazard ratio [HR], 2.53; 95% confidence interval [CI], 1.86-3.44) and RFS (HR, 2.28; 95% CI, 1.67-3.11), with low-to-moderate heterogeneity. Postoperative ctDNA positivity demonstrated stronger associations with worse OS (HR, 5.15; 95% CI, 1.57-16.88) and RFS (HR, 3.12; 95% CI, 2.01-4.82), with moderate-to-substantial heterogeneity. Preoperative CTC positivity was associated with inferior RFS (HR, 2.70; 95% CI, 1.32-5.52), with substantial heterogeneity. In individual studies, EV-based biomarkers demonstrated consistent adverse outcomes. However, quantitative pooling was not feasible due to marked heterogeneity. In resected PDAC, preoperative ctDNA is a robust predictor of recurrence and survival. Both CTCs and EVs show biologically compelling but assay-dependent prognostic signals.

PMID 42665699
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PubMedJournal of molecular modeling2026-08-29

DFT study of selective hydrogenation of non-conjugated dienes on a Pd surface: the case of 2,5-norbornadiene.

Shamsiev Ravshan S RS, Gomonyuk Varvara A VA, Flid Vitaly R VR

In this work a DFT modeling of various routes of hydrogenation of a non-conjugated bicyclic diene-norbornadiene (NBD)-was carried out using the all-electron scalar-relativistic approximation. According to calculations, the determining role in selective hydrogenation of NBD to norbornene (NBE) belongs to the type of palladium surface and adsorption configuration (exo or endo) of NBD and NBE molecules. Pd(111) surface shows selectivity in NBD adsorption, as well as activity in selective hydrogenation of NBD to NBE. Gibbs activation energies of hydrogenation of NBD to NBE and NBE to NB on Pd(111) differ by 4.3 kcal/mol in favor of the former route, which determines the selectivity of NBD hydrogenation. Formation of byproduct nortricyclane (NTC) involves overcoming a large Gibbs activation energy (29.2 kcal/mol), explaining its experimental trace amounts. Despite the high selectivity of Pd(100) surface in NBD adsorption, it is almost inactive in its hydrogenation. Notably, Gibbs activation energy of hydrogenation route of NBD to NBE on Pd(100) is 5.2 kcal/mol higher than that of NBE to NB on Pd(100) and 9.2 kcal/mol higher than that of NBD to NBE on Pd(111). Despite the significant increase in the adsorption energies of NBD and NBE, that was calculated with Grimme's D3 dispersion corrections, most of this difference is compensated when calculating activation energy. Main DFT calculations were carried out using the scalar-relativistic approximation. The PBE exchange-correlation functional and all-electron basis sets L2 for C and H atoms and L11 for Pd atoms were used. The Pd(111) and Pd(100) surfaces were modeled as 3-layered flat clusters Pd70 and Pd73, respectively. Geometry optimization for key intermediates and TSs using the PBE-D3(BJ) functional, def2-TZVP basis sets, and def2-ECP pseudopotentials was performed in ORCA 6.1.1 software. For the most energetically favorable adsorption configurations of NBD and NBE molecules, DFT-PBE and PBE-D3(BJ) calculations were performed under periodic boundary conditions in CP2K software.

PMID 42667421
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PubMedOphthalmology science2026-08-29

Molecular and Clinical Analyses of 111 Patients with Bilateral Anterior-Segment Dysgenesis/Aniridia and Microphthalmia/Anophthalmia.

Nishina Sachiko S, Anzai Hazuki H, Yoshida Tomoyo T, Koyanagi Yoshito Y et al.

To clarify the molecular and clinical characteristics of anterior-segment dysgenesis (ASD)/aniridia and microphthalmia/anophthalmia caused by monogenic variants. Clinical and genetic analyses of a large cohort of patients with bilateral ocular lesions. A total of 111 patients and their family members were recruited through a multicenter collaborative study in Japan. Next-generation sequencing using custom-designed panels for 11 and 12 major causative genes for ASD/aniridia and microphthalmia/anophthalmia, respectively. We analyzed the clinical information of patients with pathogenic or likely pathogenic variants. Collated genetic results and clinical data. We achieved genetic diagnosis rates of 50.0% for ASD/aniridia and 37.5% for microphthalmia/anophthalmia. We identified 11 previously unreported variants. De novo variants in the PAX6, PITX2, or GJA8 genes and parentally derived variants in the FOXC1 and CYP1B1 genes were the major causes of ASD/aniridia. Microphthalmia/anophthalmia‑associated variants in the ABCB6, BMP4, and OTX2 genes were predominantly inherited from parents with no or different ocular phenotypes. We observed phenotypic diversity and variable ocular and systemic complications in variant-positive patients. Most importantly, this study showed a high incidence of glaucoma in patients with CYP1B1 and FOXC1 variants and frequent systemic abnormalities in patients with FOXC1 and PITX2 variants. In addition, BMP4 and RARB variants were associated with neurologic abnormalities. This study provides evidence that targeted gene panel approaches are useful for the clinical diagnosis of ASD/aniridia and microphthalmia/anophthalmia. Our data clarified the mutation spectrum and phenotypic characteristics of these disorders caused by monogenic variants. This study confirmed that various phenotypes classified as ASD, such as Peters anomaly and Axenfeld anomaly, constitute a group of disorders on the same spectrum, may overlap with aniridia, and exhibit genetic heterogeneity. The findings, which demonstrate an association between genotypes and complications, are expected to contribute to better management and care for children with these rare intractable eye diseases. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

PMID 42667103
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