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estradiol valerate + MPA (Divina / E2V + MPA, Orion / Klimalet)

✓ Approved

HyundaiPharm · ESR1 · Small Molecule

What is estradiol valerate + MPA?

estradiol valerate + MPA is a small molecule developed by HyundaiPharm. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDivina, E2V + MPA, Orion, Klimalet
CompanyHyundaiPharm
Drug ClassSmall Molecule
Molecular TargetESR1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, HyundaiPharm

Mechanism of Action

Molecular Targets

estradiol valerate + MPA acts on 1 molecular target:

ESR1estrogen receptor 1 (ER, ESR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

estradiol valerate + MPA is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresHormone replacement therapy✓ Approved

Related Research Articles

PubMedMaterials (Basel, Switzerland)2026-10-16

Finite Element Analysis of the Load-Bearing Components of a Stackable Surgical Guide System During Flapless Implant Osteotomy in a Fully Edentulous Maxilla.

Ghionea Ionut Gabriel IG, Cristache Corina Marilena CM, Dumitru Stefan Cristian SC, Tarba Cristian Ioan CI et al.

Stackable surgical templates enable flapless, prosthetically driven implant placement and immediate provisionalization in full-arch rehabilitation; however, intraoperative guide fracture remains a recognized complication, and the biomechanical behavior of the multi-component assembly on the edentulous maxilla has not been fully characterized. This in silico study used 3D modeling, surface refinement and finite element analysis (CATIA V5) to evaluate stress and displacement distribution in a model comprising the maxilla, polymeric base guide, implant osteotomy guide, and five grade-4 titanium fixation pins, derived from a prosthetically driven virtual plan. Materials were modeled as homogeneous, isotropic, and linearly elastic. A maximum simulated axial drilling force of 10.14 N and an associated equivalent torsional load derived from the calculated cutting torque were applied for a 2 mm diameter osteotomy under Scenario 1 (idealized no-sliding contact) and Scenario 2 (frictional contact). Under Scenario 1, the maximum von Mises stresses were 2.34 MPa in the Maxilla, 3.18 MPa in the Base guide, 4.32 MPa in the Implant osteotomy guide, and 1.13-3.26 MPa in the Fixation pins. The highest polymer stress occurred in the Implant osteotomy guide (4.32 MPa; 7.2% of the 60 MPa reference strength). Under Scenario 2, the maximum stresses were 2.48 MPa in the Maxilla, 7.63 MPa in the Base guide, 2.38 MPa in the Implant osteotomy guide, and 1.11-3.94 MPa in the Fixation pins, with the Base guide showing the highest polymer utilization (7.63 MPa; 12.7%). Across both contact formulations, the polymeric guide components exhibited greater relative material utilization than the grade-4 titanium fixation pins. The maximum predicted guide-component deformation was 0.093 mm. Within the assumptions and limitations of the model, these findings indicate that the mechanical response of the assembly is more strongly influenced by the polymeric guide components, while the distribution of stress between individual guide components depends on the assumed contact scenario.

PMID 42882602
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PubMedPolymers2026-10-16

Mechanical Recovery of Damaged Glass Fiber Reinforced Polypropylene via Repetitive Sub-Melting Thermal Annealing: A Molecular and Structural Study.

Takayama Tetsuo T, Funabashi Jun J

This study clarifies the mechanical recovery and structural retention of damaged glass fiber-reinforced polypropylene (PP/GF) composites subjected to repetitive sub-melting thermal annealing at 160 °C. Initial thermal annealing increased matrix crystallinity from 0.30 to 0.37 (+23.3%), thereby elevating flexural strength from 103 MPa to 122 MPa (+18.4%). Following one repair cycle, flexural strength was completely restored to 103-105 MPa (100% recovery rate). However, after three repair cycles, short-duration annealing (120 s) resulted in severe mechanical degradation down to 30 MPa (-70.9%), whereas long-duration annealing (1800 s) retained a strength of 59 MPa (-42.7%, preserving 57.3% of initial strength). Concurrently, the crystallinity index increased to 0.49 (+63.3%) for 1800 s. These results establish that extended dwell time at sub-melting temperatures is essential for promoting molecular chain re-entanglement while suppressing void growth. These findings present an engineering guideline for low-energy, structure-preserving repair of thermoplastic composites.

PMID 42885071
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PubMedFoods (Basel, Switzerland)2026-10-16

Effects of High Hydrostatic Pressure Processing on Potential Allergenicity and Quality of Tropomyosin in Pre-Prepared Crab Products (Portunus trituberculatus).

Huang Surong S, Xu Min M, Chen Tingru T, Cai Shuilin S et al.

This study investigated the effects of high hydrostatic pressure (HHP; 200 MPa for 5-15 min) on tropomyosin (TM) immunoreactivity, in vitro digestive stability, and selected quality attributes of crab cakes prepared from Portunus trituberculatus. Western blotting and competitive indirect ELISA (ic ELISA) revealed that 200 MPa treatment significantly reduced TM IgG binding capacity, with the greatest reduction (21.19% decrease, p < 0.05) at 10 min. In vitro digestion showed that TM degraded most rapidly in simulated gastric and intestinal fluids following 200 MPa for 10 min. HHP treatment significantly enhanced water-holding capacity by converting free water to bound water, with optimal retention at 200 MPa for 10 min. Texture analysis indicated that the treatment at 200 MPa for 10 min showed outstanding performance in chewiness and made the crab cakes brighter and more reddish-yellow in color. Sensory evaluation confirmed that HHP-treated samples closely resembled conventionally cooked products in flavor and taste, exhibiting good acceptability. Overall, 200 MPa for 10 min was identified as the optimal HHP treatment condition under the present experimental conditions, as it significantly reduced the IgG-binding capacity of TM while synergistically improving water-holding capacity, texture, color, flavor, and taste stability of crab cakes. Therefore, this provides a feasible technical pathway for the development of high-quality pre-prepared crustacean foods with reduced immunoreactivity.

PMID 42883580
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PubMedPolymers2026-10-16

Geopolymer-Derived Aluminosilicate Matrix Composites Reinforced with Continuous Nickel-Coated Carbon Fibers: Tensile Properties and Thermo-Oxidative Behavior.

Jasiczek Michal M, Bobrowska Marcelina M, Jedral Arnold A

This study aims to evaluate the feasibility of an aluminosilicate geopolymer composite reinforced with continuous nickel-coated carbon fibers and establish its baseline mechanical properties and thermo-oxidative behavior. Unidirectional and balanced cross-ply laminates were fabricated via slurry impregnation, drum winding, and autoclave consolidation. The as-fabricated laminates exhibited a bulk density of 1.94 ± 0.16 g/cm3 and an apparent porosity of 23.8 ± 2.5%. For the [0]8 laminates, the mean tensile strength was 827.0 MPa at room temperature, 832.1 MPa at 371 °C, 745.7 MPa at 427 °C, and 365.5 MPa at 538 °C. Temperature-dependent failure modes shifted from predominantly longitudinal splitting up to 371 °C, to mixed splitting and fiber-dominated tensile fracture within the gauge section at 427 °C, and finally to brittle, fiber-dominated tensile fracture with no apparent fiber pull-out at 538 °C. Thermo-oxidative studies showed that the net mass loss of the coupons remained below 0.4% after 1000 h at 316 °C but reached approximately 4.7% after 336 h at 371 °C. The sections examined after exposure at 371 °C showed non-uniform filament thinning. These results establish a baseline mechanical and thermo-oxidative characterization for the proposed material system and identify prolonged oxidation as a limitation requiring further evaluation.

PMID 42885078
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PubMedMaterials (Basel, Switzerland)2026-10-16

Interpretable Machine Learning for Compressive Strength Prediction of GGBS-Fly Ash Blended Concrete: Generalization Across Training-Set Compositions and Feature-Attribution Sensitivity.

Peng Junlong J, Zhu Xuhang X

Supplementary cementitious materials (SCMs), particularly ground granulated blast-furnace slag (GGBS) and fly ash, are widely used in concrete, but the effect of training-set SCM composition on prediction of GGBS-fly ash blended mixtures remains insufficiently examined. Six regression algorithms were compared using formulation-grouped nested cross-validation, after which the retained algorithm was optimized on the complete development set and evaluated on a formulation-disjoint hold-out set. The retained model was then examined under six training-set compositions on the same GGBS-fly ash blended hold-out subset, with additional analyses of training-set size, blended-formulation exposure, hyperparameter sensitivity, and SHAP attribution under alternative feature representations. XGBoost achieved a mean outer-fold RMSE of 5.396 MPa and a hold-out RMSE of 5.095 MPa; on the blended subset, training on all mixture types and on blended mixtures only yielded RMSEs of 5.372 and 5.346 MPa, respectively, compared with 7.095 MPa when blended formulations were excluded, while SCM SHAP attributions varied across feature representations. The retained XGBoost model showed that blended-mixture prediction performance within this dataset varied with training-set SCM composition and blended-domain representation, while SCM feature attributions varied with input representation.

PMID 42882713
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PubMedMaterials (Basel, Switzerland)2026-10-16

Processing-Route Dependence and Adhesion of Polymer-Adhesive-Steel Interfaces with Recycled PA6/GF30 Composites Modified with Functional Additives: Injection Molding Versus Large-Format Fused Granulate Fabrication.

Przekop Robert E RE, Frydrych Miłosz M, Kubiak Natalia N, Nowak Krzysztof K et al.

Large-scale additive manufacturing (LSAM) using fused granulate fabrication (FGF) offers a potential route for the high-value utilization of recycled thermoplastic composites. This study investigated recycled PA6 containing nominally 30 wt.% glass fibers as a candidate feedstock for large-format FGF. An unmodified reference and formulations containing SF315/PTFE, SF315/U15, and MIX-OH were examined. The granulates were characterized using melt mass flow rate measurements, thermogravimetric analysis, and differential scanning calorimetry, while mechanical properties were compared after injection molding and FGF processing. The best FGF performance was obtained for SF315/PTFE (polytetrafluoroethylene) and SF315/U15. Their tensile strengths reached 117.3 and 118.7 MPa, respectively, compared with 56.8 MPa for the FGF-processed reference. Flexural strengths reached 158.8 and 152.4 MPa, respectively, versus 88.0 MPa for the reference. The tensile and flexural improvements produced by MIX-OH after injection molding were not retained after FGF processing, confirming strong processing-route dependence. Preliminary pull-off screening demonstrated that TPU-bonded polymer-steel joints could be produced. Under the investigated conditions, SF315/PTFE and SF315/U15 were identified as promising recycled PA6/GF30 formulations for large-format FGF and further tooling-oriented development.

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