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Therapeutic Indications
Brizantin is developed for 1 unique indication across 1 therapeutic area.
Therapeutic Area
Condition
Phase
Psychiatric disorders
Nicotine dependence
✓ Approved
Related Research Articles
PubMedDose-response : a publication of International Hormesis Society2018-07-18
Dose-Response Effect of Antibodies to S100 Protein and Cannabinoid Receptor Type 1 in Released-Active Form in the Light-Dark Test in Mice.
Kardash Elena V EV, Ertuzun Irina A IA, Khakimova Gul'nara R GR, Kolyadin Andrey N AN et al.
Earlier studies have shown that combination of antibodies to S100 protein and to cannabinoid receptor type 1 in released-active form (Brizantin) may possess anxiolytic properties and decrease nicotine dependence. Released-active form of antibodies is a novel approach that permits to modify natural functions of the target molecule (antigen) under investigation. The aim of the present study was to evaluate the anxiolytic-like effect of Brizantin in the light-dark test in mice, according to its ability to influence the number of entries into the lit compartment and the total time spent there. Three doses of Brizantin (2.5, 5, and 10 mL/kg) were compared with diazepam (1 mg/kg), placebo, and vehicle control. Anxiolytic-like effect of the tested drug was shown to be dose dependent, with an increasing trend from 2.5 to 10 mL/kg. Brizantin in its highest dose significantly increased studied behavioral parameters, although its effect was less pronounced than that of the reference drug diazepam (1 mg/kg).
PubMedZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova2016-07-08
[Farmacological effects of anti-S 100 in release-active form and mechanisms of their realization].
Khakimova G R GR, Voronina T A TA, Dugina Yu L YL, Ertuzun I A IA et al.
Antibodies to 5100 proteins (anti-5100) in release-active form (RA anti-5100) are an active component of some domestic drugs(tenoten, tenoten for children, divaza, brizantin, kolofort and proproten-100). The authors present the results of preclinical and clinical trials (with detailed consideration of experimental data) which demonstrated a wide spectrum of specific pharmacological activity and safety as well as mechanisms of anti-5100 action.
PubMedBulletin of experimental biology and medicine2015-11-27
The Use of Release-Active Antibody-Based Preparations for Vertigo Prevention in Adults.
Barchukov V V VV, Zhavbert E S ES, Dugina Yu L YL, Epstein O I OI
The effectiveness of antibody-based release-active preparations Impaza (antibodies to eNOS), Tenoten (antibodies to brain-specific protein S-100), Dietressa (antibodies to type 1 cannabinoid receptor), Brizantin (combined preparation, antibodies to brain-specific protein S-100 and type 1 cannabinoid receptor), and Divaza (combined preparation, antibodies to brain-specific protein S-100 and eNOS) in the prevention of vertigo was studied on the model of intermittent accumulation of Coriolis accelerations (ICCA). Modification of activity of vestibular receptors and signal systems by release-active preparations contributed to an increase in ICCA tolerance time. Combined preparation Impaza possessed the most significant antinaupathic properties. Brizantin was less potent in this respect.
PubMedBulletin of experimental biology and medicine2015-11-01
Anxiolytic and Antidepressant Effects of Divaza and Brizantin.
Yakovleva N N NN, Voronina T A TA, Suslov N I NI, Ertuzun I A IA et al.
The anxiolytic and antidepressant activities of complex preparations divaza and brizantin containing antibodies to brain-specific protein S100 were estimated using Vogel conflict test and Nomura forced swimming test. Course treatment (5 days) of brizantin in a dose of 2.5 ml/kg and divaza in a dose of 7.5 ml/kg significantly increased punished drinking in the Vogel conflict test in comparison with the control. Both drugs also improved general emotional behavior during training prior to the test procedure. Brizantin and divaza in a dose of 7.5 ml/kg increased the number of wheel revolutions in the Nomura forced swimming test in comparison with the control; the effect of divaza was more pronounced. High correlation coefficients between the number of wheel revolutions during the first and second 5-min sessions are also indicative of antidepressant action of divaza and brizantin.
PubMedBulletin of experimental biology and medicine2013-03-14
Experimental study on the efficacy of the drug Brizantin in the model of nicotine dependence.
Kheyfets I A IA, Vorob'eva T M TM, Veselovskaya E V EV, Shlyahova A V AV et al.
We estimated the efficacy of Brizantin preparation in suppressing nicotine dependence in rats. It was shown that nicotine-dependent rats in the situation of choice between the chamber with smoke or the chamber with food more frequently entered the chamber with tobacco smoke and stayed there longer. The rats that received Brizantin demonstrated significantly fewer visits to the chamber with smoke and spent there less time. Reduced locomotor activity and orientation and exploratory behavior in rats against the background of Brizantin administration also suggest reduced motivation for smoke inhalation. Thus, Brizantin effectively diminished nicotine dependence in rats in the model of nicotine addiction.