Ambience Healthcare Secures $243M in Series C Funding, Pushing Valuation to $1.25B

Ambient AI platform Ambience Healthcare has raised $243 million in a Series C funding round, catapulting the company's valuation to $1.25 billion. This significant investment marks one of the largest health tech raises in 2025 and signals continued investor confidence in the burgeoning healthcare AI market.

Funding Details and Investor Lineup

The funding round was co-led by Oak HC/FT and Andreessen Horowitz (a16z), with participation from existing investors including the OpenAI Startup Fund, Kleiner Perkins, and Optum Ventures. New investors joining the round include Frist Cressey Ventures, Town Hall Ventures, Smash Capital, Georgian, and Founders Circle Capital.

This latest investment brings Ambience's total funding to $345 million, following a $70 million Series B round in February 2024. The company plans to utilize the new capital to expand its reach to more health systems and develop additional products.

Ambience's AI-Powered Healthcare Solutions

Ambience's platform leverages AI technology for medical documentation, clinical documentation integrity, and point-of-care coding. The company's solution goes beyond simple transcription, generating accurate, compliant, and specialty-aware clinical notes and codes in real-time.

Key features of Ambience's technology include:

• Automated documentation through ambient listening
• Specialty-specific chart summaries
• Comprehensive medical note generation
• Built-in ICD-10 assistant and real-time compliance engine
• Customized after-visit summaries for patients

The platform integrates directly with electronic health records and supports over 200 medical specialties, including complex domains such as oncology, psychiatry, and emergency medicine. Ambience claims its solution can reduce charting time by 45%, significantly easing the documentation burden on healthcare providers.

Adoption and Partnerships

Ambience's ambient AI technology has been deployed by more than 40 U.S. health systems, including prominent institutions such as Cleveland Clinic, UCSF Health, Houston Methodist, and Memorial Hermann. The company reports that adoption has been particularly rapid in high-complexity subspecialties, emergency departments, and inpatient settings.

Notably, Cleveland Clinic has entered into an exclusive five-year partnership with Ambience following a comprehensive six-month pilot that evaluated five major ambient scribe vendors. The health system's extensive testing revealed significant differences in documentation quality among the vendors, with Ambience emerging as the preferred solution.

As the healthcare industry continues to embrace AI-driven solutions, Ambience Healthcare's substantial funding and growing partnerships position the company as a leader in transforming clinical workflows and improving healthcare delivery through innovative technology.