Pfizer and Flagship Expand Collaboration to Tackle Obesity and Lung Cancer

Pfizer and Flagship Pioneering have strengthened their partnership by collaborating with two Flagship-founded companies, Ampersand Biomedicines and Montai Therapeutics, to develop innovative treatments for obesity and lung cancer, respectively. Ampersand is focusing on biologic medicines targeting tissue-specific metabolic pathways to improve metabolic health and tackle obesity, marking a reinvigorated attempt at addressing this critical health issue in their expanded agreement[1][2]. Meanwhile, Montai Therapeutics is utilizing its CONECTA platform to discover small molecule drugs that target cancer cell growth mechanisms in lung cancer. Both ventures fall under the broader scope of the "Pioneering Medicines" initiative, aiming to discover up to 10 new drugs, thereby leveraging the extensive research and resources from Flagship’s portfolio of startups[2].
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What specific research breakthroughs have Ampersand Biomedicines and Montai Therapeutics made in their respective areas of obesity and lung cancer under the Pfizer and Flagship collaboration?
How might Ampersand's AND platform specifically address the challenges of targeting tissue-specific metabolic pathways in obesity treatment?
What are the potential implications of Montai Therapeutics' CONECTA platform for the future of lung cancer treatments?
Given Ampersand's and Montai's involvement, how does the collaboration plan to measure success in their fight against obesity and lung cancer?
What strategies or technologies do Pfizer and Flagship plan to deploy to identify and develop up to ten new drug candidates through this partnership?